Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP

Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP

Processing of amyloid beta precursor protein (APP) into amyloid-beta peptide (Aβ) by β-secretase and γ-secretase complex is at the heart of the pathogenesis of Alzheimer’s disease (AD). Targeting this proteolytic pathway effectively reduces/prevents pathology and cognitive decline in preclinical exp...

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Bibliographic Details
Main Authors: Laura García-González, Dominika Pilat, Kévin Baranger, Santiago Rivera
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
amyloid precursor protein
matrix metalloproteinases
eta-secretase
meprin-beta
legumain
rhomboid-like protein-4
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00244/full

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