Orbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning task
Using knowledge of the structure of the world to infer value is at the heart of model-based reasoning and relies on a circuit that includes the orbitofrontal cortex (OFC). Some accounts link this to the representation of biological significance or value by neurons in OFC, while other models focus on...
| Principais autores: | , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
eLife Sciences Publications Ltd
2018-03-01
|
| coleção: | eLife |
| Assuntos: | |
| Acesso em linha: | https://elifesciences.org/articles/30373 |
| _version_ | 1828222091692867584 |
|---|---|
| author | Brian F Sadacca Heather M Wied Nina Lopatina Gurpreet K Saini Daniel Nemirovsky Geoffrey Schoenbaum |
| author_facet | Brian F Sadacca Heather M Wied Nina Lopatina Gurpreet K Saini Daniel Nemirovsky Geoffrey Schoenbaum |
| author_sort | Brian F Sadacca |
| collection | DOAJ |
| description | Using knowledge of the structure of the world to infer value is at the heart of model-based reasoning and relies on a circuit that includes the orbitofrontal cortex (OFC). Some accounts link this to the representation of biological significance or value by neurons in OFC, while other models focus on the representation of associative structure or cognitive maps. Here we tested between these accounts by recording OFC neurons in rats during an OFC-dependent sensory preconditioning task. We found that while OFC neurons were strongly driven by biological significance or reward predictions at the end of training, they also showed clear evidence of acquiring the incidental stimulus-stimulus pairings in the preconditioning phase, prior to reward training. These results support a role for OFC in representing associative structure, independent of value. |
| first_indexed | 2024-04-12T16:49:32Z |
| format | Article |
| id | doaj.art-0bc06e21a3c146f18b75dba5f1cb0f4b |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:49:32Z |
| publishDate | 2018-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-0bc06e21a3c146f18b75dba5f1cb0f4b2022-12-22T03:24:26ZengeLife Sciences Publications LtdeLife2050-084X2018-03-01710.7554/eLife.30373Orbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning taskBrian F Sadacca0Heather M Wied1Nina Lopatina2Gurpreet K Saini3Daniel Nemirovsky4Geoffrey Schoenbaum5https://orcid.org/0000-0001-8180-0701Intramural Research program of the National Institute on Drug Abuse, NIH, Baltimore, United StatesIntramural Research program of the National Institute on Drug Abuse, NIH, Baltimore, United StatesIntramural Research program of the National Institute on Drug Abuse, NIH, Baltimore, United StatesIntramural Research program of the National Institute on Drug Abuse, NIH, Baltimore, United StatesIntramural Research program of the National Institute on Drug Abuse, NIH, Baltimore, United StatesIntramural Research program of the National Institute on Drug Abuse, NIH, Baltimore, United States; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, United States; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, United StatesUsing knowledge of the structure of the world to infer value is at the heart of model-based reasoning and relies on a circuit that includes the orbitofrontal cortex (OFC). Some accounts link this to the representation of biological significance or value by neurons in OFC, while other models focus on the representation of associative structure or cognitive maps. Here we tested between these accounts by recording OFC neurons in rats during an OFC-dependent sensory preconditioning task. We found that while OFC neurons were strongly driven by biological significance or reward predictions at the end of training, they also showed clear evidence of acquiring the incidental stimulus-stimulus pairings in the preconditioning phase, prior to reward training. These results support a role for OFC in representing associative structure, independent of value.https://elifesciences.org/articles/30373orbitofrontalpreconditioningmodel-basedinferencesingle unit |
| spellingShingle | Brian F Sadacca Heather M Wied Nina Lopatina Gurpreet K Saini Daniel Nemirovsky Geoffrey Schoenbaum Orbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning task eLife orbitofrontal preconditioning model-based inference single unit |
| title | Orbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning task |
| title_full | Orbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning task |
| title_fullStr | Orbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning task |
| title_full_unstemmed | Orbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning task |
| title_short | Orbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning task |
| title_sort | orbitofrontal neurons signal sensory associations underlying model based inference in a sensory preconditioning task |
| topic | orbitofrontal preconditioning model-based inference single unit |
| url | https://elifesciences.org/articles/30373 |
| work_keys_str_mv | AT brianfsadacca orbitofrontalneuronssignalsensoryassociationsunderlyingmodelbasedinferenceinasensorypreconditioningtask AT heathermwied orbitofrontalneuronssignalsensoryassociationsunderlyingmodelbasedinferenceinasensorypreconditioningtask AT ninalopatina orbitofrontalneuronssignalsensoryassociationsunderlyingmodelbasedinferenceinasensorypreconditioningtask AT gurpreetksaini orbitofrontalneuronssignalsensoryassociationsunderlyingmodelbasedinferenceinasensorypreconditioningtask AT danielnemirovsky orbitofrontalneuronssignalsensoryassociationsunderlyingmodelbasedinferenceinasensorypreconditioningtask AT geoffreyschoenbaum orbitofrontalneuronssignalsensoryassociationsunderlyingmodelbasedinferenceinasensorypreconditioningtask |