Association of ERCC5 Genetic Polymorphisms With Cirrhosis and Liver Cancer
Introduction: To explore association of excision repair cross-complementing 5 ( ERCC5 ) genetic polymorphisms with cirrhosis and liver cancer. Methods: A total of 365 patients were enrolled, including control group (n = 133), cirrhosis group (n = 122), and liver cancer group (n = 110). The genotypin...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-08-01
|
| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/1533033820943244 |
| _version_ | 1818341209485082624 |
|---|---|
| author | Gang Yang MM Yuxia Yang BD Xin Ma BD Lijun Huang MM Wenbin Li MM Xuejuan Song BD Huiqin Zhang MM Wenwen Liu BD Juanjuan Lu MM |
| author_facet | Gang Yang MM Yuxia Yang BD Xin Ma BD Lijun Huang MM Wenbin Li MM Xuejuan Song BD Huiqin Zhang MM Wenwen Liu BD Juanjuan Lu MM |
| author_sort | Gang Yang MM |
| collection | DOAJ |
| description | Introduction: To explore association of excision repair cross-complementing 5 ( ERCC5 ) genetic polymorphisms with cirrhosis and liver cancer. Methods: A total of 365 patients were enrolled, including control group (n = 133), cirrhosis group (n = 122), and liver cancer group (n = 110). The genotyping of ERCC5 rs2016073, rs751402, rs2094258, rs2296147, and rs2296148 was measured by using MassARRAY iPLEX technology. Results: There were no significant differences in gender and drinking among the 3 groups ( P > .05). There were significant differences among the 3 groups in both age-group ≤60 and >60 subgroup patients. Locus rs2016073 was significantly different among 3 groups, and genotype GG (n = 0) was not observed in liver cancer group. As for locus rs751402, there were significant differences among 3 groups, and genotype AA (n = 0) was not observed in liver cancer group. As for locus rs2094258, there were no significant differences among 3 groups. Locus rs2296147 showed no significant differences among 3 groups ( P > .05), but genotype CC was not observed in liver cancer group (n = 0). As for locus rs2296148, there were significant differences among 3 groups, and genotype TC (n = 0) was not observed in cirrhosis group. Regression analysis found locus rs751402 had significant difference between control group and cirrhosis group, patients with genotype AA and genotype GG were more likely to have cirrhosis than those with genotype GA. Conclusion: Our study suggested that genotype AA, genotype GG of ERCC5 locus rs751402, and genotype TC of locus rs2296148 may be important targets for cirrhosis, while ERCC5 polymorphisms (rs2016073 and ERCC5 polymorphisms, rs2016073 with genotype GG, and rs751402 with genotype AA) may be potential markers for liver cancer. |
| first_indexed | 2024-12-13T15:55:09Z |
| format | Article |
| id | doaj.art-0bc18e2090a34f7f874869168afd967f |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-12-13T15:55:09Z |
| publishDate | 2020-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-0bc18e2090a34f7f874869168afd967f2022-12-21T23:39:20ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382020-08-011910.1177/1533033820943244Association of ERCC5 Genetic Polymorphisms With Cirrhosis and Liver CancerGang Yang MM0Yuxia Yang BD1Xin Ma BD2Lijun Huang MM3Wenbin Li MM4Xuejuan Song BD5Huiqin Zhang MM6Wenwen Liu BD7Juanjuan Lu MM8 Digestive Department, , Lanzhou, China Digestive Department, , Lanzhou, China Digestive Department, , Lanzhou, China Digestive Department, , Lanzhou, China Digestive Department, , Lanzhou, China Digestive Department, , Lanzhou, China Digestive Department, , Lanzhou, China Digestive Department, , Lanzhou, China Digestive Department, , Lanzhou, ChinaIntroduction: To explore association of excision repair cross-complementing 5 ( ERCC5 ) genetic polymorphisms with cirrhosis and liver cancer. Methods: A total of 365 patients were enrolled, including control group (n = 133), cirrhosis group (n = 122), and liver cancer group (n = 110). The genotyping of ERCC5 rs2016073, rs751402, rs2094258, rs2296147, and rs2296148 was measured by using MassARRAY iPLEX technology. Results: There were no significant differences in gender and drinking among the 3 groups ( P > .05). There were significant differences among the 3 groups in both age-group ≤60 and >60 subgroup patients. Locus rs2016073 was significantly different among 3 groups, and genotype GG (n = 0) was not observed in liver cancer group. As for locus rs751402, there were significant differences among 3 groups, and genotype AA (n = 0) was not observed in liver cancer group. As for locus rs2094258, there were no significant differences among 3 groups. Locus rs2296147 showed no significant differences among 3 groups ( P > .05), but genotype CC was not observed in liver cancer group (n = 0). As for locus rs2296148, there were significant differences among 3 groups, and genotype TC (n = 0) was not observed in cirrhosis group. Regression analysis found locus rs751402 had significant difference between control group and cirrhosis group, patients with genotype AA and genotype GG were more likely to have cirrhosis than those with genotype GA. Conclusion: Our study suggested that genotype AA, genotype GG of ERCC5 locus rs751402, and genotype TC of locus rs2296148 may be important targets for cirrhosis, while ERCC5 polymorphisms (rs2016073 and ERCC5 polymorphisms, rs2016073 with genotype GG, and rs751402 with genotype AA) may be potential markers for liver cancer.https://doi.org/10.1177/1533033820943244 |
| spellingShingle | Gang Yang MM Yuxia Yang BD Xin Ma BD Lijun Huang MM Wenbin Li MM Xuejuan Song BD Huiqin Zhang MM Wenwen Liu BD Juanjuan Lu MM Association of ERCC5 Genetic Polymorphisms With Cirrhosis and Liver Cancer Technology in Cancer Research & Treatment |
| title | Association of ERCC5 Genetic Polymorphisms With Cirrhosis and Liver Cancer |
| title_full | Association of ERCC5 Genetic Polymorphisms With Cirrhosis and Liver Cancer |
| title_fullStr | Association of ERCC5 Genetic Polymorphisms With Cirrhosis and Liver Cancer |
| title_full_unstemmed | Association of ERCC5 Genetic Polymorphisms With Cirrhosis and Liver Cancer |
| title_short | Association of ERCC5 Genetic Polymorphisms With Cirrhosis and Liver Cancer |
| title_sort | association of ercc5 genetic polymorphisms with cirrhosis and liver cancer |
| url | https://doi.org/10.1177/1533033820943244 |
| work_keys_str_mv | AT gangyangmm associationofercc5geneticpolymorphismswithcirrhosisandlivercancer AT yuxiayangbd associationofercc5geneticpolymorphismswithcirrhosisandlivercancer AT xinmabd associationofercc5geneticpolymorphismswithcirrhosisandlivercancer AT lijunhuangmm associationofercc5geneticpolymorphismswithcirrhosisandlivercancer AT wenbinlimm associationofercc5geneticpolymorphismswithcirrhosisandlivercancer AT xuejuansongbd associationofercc5geneticpolymorphismswithcirrhosisandlivercancer AT huiqinzhangmm associationofercc5geneticpolymorphismswithcirrhosisandlivercancer AT wenwenliubd associationofercc5geneticpolymorphismswithcirrhosisandlivercancer AT juanjuanlumm associationofercc5geneticpolymorphismswithcirrhosisandlivercancer |