SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation.

SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation.

Senescent cells develop a pro-inflammatory response termed the senescence-associated secretory phenotype (SASP). As many SASP components affect surrounding cells and alter their microenvironment, SASP may be a key phenomenon in linking cellular senesence with individual aging and age-related disease...

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Bibliographic Details
Main Authors: Tomohisa Hayakawa, Mika Iwai, Satoshi Aoki, Koichi Takimoto, Mitsuo Maruyama, Wakako Maruyama, Noboru Motoyama
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4312089?pdf=render

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