Predicting CRISPR/Cas9 Repair Outcomes by Attention-Based Deep Learning Framework

Predicting CRISPR/Cas9 Repair Outcomes by Attention-Based Deep Learning Framework

As a simple and programmable nuclease-based genome editing tool, the CRISPR/Cas9 system has been widely used in target-gene repair and gene-expression regulation. The DNA mutation generated by CRISPR/Cas9-mediated double-strand breaks determines its biological and phenotypic effects. Experiments hav...

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Bibliographic Details
Main Authors: Xiuqin Liu, Shuya Wang, Dongmei Ai
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
DNA repair
deep learning
positional encoding
attention mechanism
Online Access:https://www.mdpi.com/2073-4409/11/11/1847

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