Ubiquitination in the regulation of autophagy
Autophagy, an efficient and effective approach to clear rapidly damaged organelles, macromolecules, and other harmful cellular components, enables the recycling of nutrient materials and supply of nutrients to maintain cellular homeostasis....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2023-08-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2023149 |
| _version_ | 1797635863460446208 |
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| author | Cen Xueyan Li Ziling Chen Xinpeng |
| author_facet | Cen Xueyan Li Ziling Chen Xinpeng |
| author_sort | Cen Xueyan |
| collection | DOAJ |
| description | Autophagy, an efficient and effective approach to clear rapidly damaged organelles, macromolecules, and other harmful cellular components, enables the recycling of nutrient materials and supply of nutrients to maintain cellular homeostasis. Ubiquitination plays an important regulatory role in autophagy. This paper summarizes the most recent progress in ubiquitin modification in various stages of autophagy, including initiation, elongation, and termination. Moreover, this paper shows that ubiquitination is an important way through which selective autophagy achieves substrate specificity. Furthermore, we note the distinction between monoubiquitination and polyubiquitination in the regulation of autophagy. Compared with monoubiquitination, polyubiquitination is a more common strategy to regulate the activity of the autophagy molecular machinery. In addition, the role of ubiquitination in the closure and fusion of autophagosomes warrants further study. This article not only clarifies the regulatory mechanism of autophagy but also contributes to a deeper understanding of the importance of ubiquitination modification. |
| first_indexed | 2024-03-11T12:26:19Z |
| format | Article |
| id | doaj.art-0bc37fde80aa4f97b5d91136f1f48740 |
| institution | Directory Open Access Journal |
| issn | 1672-9145 |
| language | English |
| last_indexed | 2024-03-11T12:26:19Z |
| publishDate | 2023-08-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj.art-0bc37fde80aa4f97b5d91136f1f487402023-11-06T08:30:37ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452023-08-01551348135710.3724/abbs.202314920d259ccUbiquitination in the regulation of autophagyCen Xueyan0Li Ziling1Chen Xinpeng2["Hubei Key laboratory of Edible Wild Plants Conservation & Utilization, Hubei Engineering Research Center of Special Wild Vegetables Breeding and Comprehensive Utilization Technology, School of Life Science, Hubei Normal University, Huangshi 435002, China"]["Hubei Key laboratory of Edible Wild Plants Conservation & Utilization, Hubei Engineering Research Center of Special Wild Vegetables Breeding and Comprehensive Utilization Technology, School of Life Science, Hubei Normal University, Huangshi 435002, China"]["Hubei Key laboratory of Edible Wild Plants Conservation & Utilization, Hubei Engineering Research Center of Special Wild Vegetables Breeding and Comprehensive Utilization Technology, School of Life Science, Hubei Normal University, Huangshi 435002, China","National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China"]Autophagy, an efficient and effective approach to clear rapidly damaged organelles, macromolecules, and other harmful cellular components, enables the recycling of nutrient materials and supply of nutrients to maintain cellular homeostasis. Ubiquitination plays an important regulatory role in autophagy. This paper summarizes the most recent progress in ubiquitin modification in various stages of autophagy, including initiation, elongation, and termination. Moreover, this paper shows that ubiquitination is an important way through which selective autophagy achieves substrate specificity. Furthermore, we note the distinction between monoubiquitination and polyubiquitination in the regulation of autophagy. Compared with monoubiquitination, polyubiquitination is a more common strategy to regulate the activity of the autophagy molecular machinery. In addition, the role of ubiquitination in the closure and fusion of autophagosomes warrants further study. This article not only clarifies the regulatory mechanism of autophagy but also contributes to a deeper understanding of the importance of ubiquitination modification.https://www.sciengine.com/doi/10.3724/abbs.2023149monoubiquitinationpolyubiquitinationautophagy molecule machineselective autophagy |
| spellingShingle | Cen Xueyan Li Ziling Chen Xinpeng Ubiquitination in the regulation of autophagy Acta Biochimica et Biophysica Sinica monoubiquitination polyubiquitination autophagy molecule machine selective autophagy |
| title | Ubiquitination in the regulation of autophagy |
| title_full | Ubiquitination in the regulation of autophagy |
| title_fullStr | Ubiquitination in the regulation of autophagy |
| title_full_unstemmed | Ubiquitination in the regulation of autophagy |
| title_short | Ubiquitination in the regulation of autophagy |
| title_sort | ubiquitination in the regulation of autophagy |
| topic | monoubiquitination polyubiquitination autophagy molecule machine selective autophagy |
| url | https://www.sciengine.com/doi/10.3724/abbs.2023149 |
| work_keys_str_mv | AT cenxueyan ubiquitinationintheregulationofautophagy AT liziling ubiquitinationintheregulationofautophagy AT chenxinpeng ubiquitinationintheregulationofautophagy |