Molecular signatures associated with HCV-induced hepatocellular carcinoma and liver metastasis.
Hepatocellular carcinomas (HCCs) are a heterogeneous group of tumors that differ in risk factors and genetic alterations. In Italy, particularly Southern Italy, chronic hepatitis C virus (HCV) infection represents the main cause of HCC. Using high-density oligoarrays, we identified consistent differ...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3575468?pdf=render |
| _version_ | 1828428929774387200 |
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| author | Valeria De Giorgi Luigi Buonaguro Andrea Worschech Maria Lina Tornesello Francesco Izzo Francesco M Marincola Ena Wang Franco M Buonaguro |
| author_facet | Valeria De Giorgi Luigi Buonaguro Andrea Worschech Maria Lina Tornesello Francesco Izzo Francesco M Marincola Ena Wang Franco M Buonaguro |
| author_sort | Valeria De Giorgi |
| collection | DOAJ |
| description | Hepatocellular carcinomas (HCCs) are a heterogeneous group of tumors that differ in risk factors and genetic alterations. In Italy, particularly Southern Italy, chronic hepatitis C virus (HCV) infection represents the main cause of HCC. Using high-density oligoarrays, we identified consistent differences in gene-expression between HCC and normal liver tissue. Expression patterns in HCC were also readily distinguishable from those associated with liver metastases. To characterize molecular events relevant to hepatocarcinogenesis and identify biomarkers for early HCC detection, gene expression profiling of 71 liver biopsies from HCV-related primary HCC and corresponding HCV-positive non-HCC hepatic tissue, as well as gastrointestinal liver metastases paired with the apparently normal peri-tumoral liver tissue, were compared to 6 liver biopsies from healthy individuals. Characteristic gene signatures were identified when normal tissue was compared with HCV-related primary HCC, corresponding HCV-positive non-HCC as well as gastrointestinal liver metastases. Pathway analysis classified the cellular and biological functions of the genes differentially expressed as related to regulation of gene expression and post-translational modification in HCV-related primary HCC; cellular Growth and Proliferation, and Cell-To-Cell Signaling and Interaction in HCV-related non HCC samples; Cellular Growth and Proliferation and Cell Cycle in metastasis. Also characteristic gene signatures were identified of HCV-HCC progression for early HCC diagnosis.A diagnostic molecular signature complementing conventional pathologic assessment was identified. |
| first_indexed | 2024-12-10T17:25:06Z |
| format | Article |
| id | doaj.art-0bc519fdb8e24a0fb2c3837ba26b9e32 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T17:25:06Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0bc519fdb8e24a0fb2c3837ba26b9e322022-12-22T01:39:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5615310.1371/journal.pone.0056153Molecular signatures associated with HCV-induced hepatocellular carcinoma and liver metastasis.Valeria De GiorgiLuigi BuonaguroAndrea WorschechMaria Lina TorneselloFrancesco IzzoFrancesco M MarincolaEna WangFranco M BuonaguroHepatocellular carcinomas (HCCs) are a heterogeneous group of tumors that differ in risk factors and genetic alterations. In Italy, particularly Southern Italy, chronic hepatitis C virus (HCV) infection represents the main cause of HCC. Using high-density oligoarrays, we identified consistent differences in gene-expression between HCC and normal liver tissue. Expression patterns in HCC were also readily distinguishable from those associated with liver metastases. To characterize molecular events relevant to hepatocarcinogenesis and identify biomarkers for early HCC detection, gene expression profiling of 71 liver biopsies from HCV-related primary HCC and corresponding HCV-positive non-HCC hepatic tissue, as well as gastrointestinal liver metastases paired with the apparently normal peri-tumoral liver tissue, were compared to 6 liver biopsies from healthy individuals. Characteristic gene signatures were identified when normal tissue was compared with HCV-related primary HCC, corresponding HCV-positive non-HCC as well as gastrointestinal liver metastases. Pathway analysis classified the cellular and biological functions of the genes differentially expressed as related to regulation of gene expression and post-translational modification in HCV-related primary HCC; cellular Growth and Proliferation, and Cell-To-Cell Signaling and Interaction in HCV-related non HCC samples; Cellular Growth and Proliferation and Cell Cycle in metastasis. Also characteristic gene signatures were identified of HCV-HCC progression for early HCC diagnosis.A diagnostic molecular signature complementing conventional pathologic assessment was identified.http://europepmc.org/articles/PMC3575468?pdf=render |
| spellingShingle | Valeria De Giorgi Luigi Buonaguro Andrea Worschech Maria Lina Tornesello Francesco Izzo Francesco M Marincola Ena Wang Franco M Buonaguro Molecular signatures associated with HCV-induced hepatocellular carcinoma and liver metastasis. PLoS ONE |
| title | Molecular signatures associated with HCV-induced hepatocellular carcinoma and liver metastasis. |
| title_full | Molecular signatures associated with HCV-induced hepatocellular carcinoma and liver metastasis. |
| title_fullStr | Molecular signatures associated with HCV-induced hepatocellular carcinoma and liver metastasis. |
| title_full_unstemmed | Molecular signatures associated with HCV-induced hepatocellular carcinoma and liver metastasis. |
| title_short | Molecular signatures associated with HCV-induced hepatocellular carcinoma and liver metastasis. |
| title_sort | molecular signatures associated with hcv induced hepatocellular carcinoma and liver metastasis |
| url | http://europepmc.org/articles/PMC3575468?pdf=render |
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