Association between whole blood essential trace elements and cognitive function in older adults
Background: Essential trace elements (ETEs) are essential nutrients for keeping the nervous system functioning. Associations between ETEs and cognitive function are still inconclusive and limited. Objectives: We aimed to investigate the individual and joint associations between ETEs and cognitive fu...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323006188 |
| _version_ | 1797803970712829952 |
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| author | Yao-yao Lin Lin Meng Fan-jia Guo Xin-han Zhang Dan-dan Yang Xue-cheng Yao Ming-juan Jin Jian-bing Wang Meng-ling Tang Kun Chen |
| author_facet | Yao-yao Lin Lin Meng Fan-jia Guo Xin-han Zhang Dan-dan Yang Xue-cheng Yao Ming-juan Jin Jian-bing Wang Meng-ling Tang Kun Chen |
| author_sort | Yao-yao Lin |
| collection | DOAJ |
| description | Background: Essential trace elements (ETEs) are essential nutrients for keeping the nervous system functioning. Associations between ETEs and cognitive function are still inconclusive and limited. Objectives: We aimed to investigate the individual and joint associations between ETEs and cognitive function among older adults. Methods: A population (N = 2181) at an average age≥ 65 from Yiwu cohort in China was available for this study. Whole blood chromium (Cr), selenium (Se), manganese (Mn), and copper (Cu) concentrations were measured by inductively coupled plasma mass spectrometry (ICP-MS). Cognitive function was assessed using the Mini-Mental State Examination (MMSE), consisting of five specific cognitive domains: orientation, registry, attention and calculation, recall, and language and praxis. Linear regression, restricted cubic spline (RCS) analysis, and Bayesian kernel machine regression (BKMR) were used to analyze the individual and joint associations between ETEs and cognitive function. Results: The association between Cr and MMSE score presented an inverted-U shape (Q3 versus Q1: β = 0.774, 95 % CI: 0.297, 1.250; Q4 versus Q1: β = 0.481, 95 % CI: 0.006, 0.956); and Cr was especially associated with the registry, recall, and language and praxis. Per IQR (36.32 μg/L) increase of Se was positively associated with the MMSE score (β = 0.497, 95 % CI: 0.277, 0.717) and all five cognitive domains. The BKMR showed that the dose-response association between Se and cognitive function increased initially and then decreased with increasing Se concentration when fixed the other ETEs in median. ETEs mixture was positively associated with cognitive function, and Se (posterior inclusion probabilities, PIPs = 0.915) was the most important contributor within the ETEs mixture. Conclusions: The nonlinear association between Cr and cognitive function suggested further exploration of an appropriate concentration range for ETEs. A positive association between mixed ETEs and cognitive function is a reminder that their joint association should be considered. Further prospective studies or intervention studies are warranted to validate our findings in the future. |
| first_indexed | 2024-03-13T05:30:07Z |
| format | Article |
| id | doaj.art-0bc59282eba44a2bbac616b9d03ed904 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-13T05:30:07Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-0bc59282eba44a2bbac616b9d03ed9042023-06-15T04:54:09ZengElsevierEcotoxicology and Environmental Safety0147-65132023-08-01261115114Association between whole blood essential trace elements and cognitive function in older adultsYao-yao Lin0Lin Meng1Fan-jia Guo2Xin-han Zhang3Dan-dan Yang4Xue-cheng Yao5Ming-juan Jin6Jian-bing Wang7Meng-ling Tang8Kun Chen9Department of Public Health, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Public Health, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Public Health, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu 322000, ChinaDepartment of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Public Health, National Clinical Research Center for Child Health of Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Public Health, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Corresponding authors.Department of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Corresponding authors.Background: Essential trace elements (ETEs) are essential nutrients for keeping the nervous system functioning. Associations between ETEs and cognitive function are still inconclusive and limited. Objectives: We aimed to investigate the individual and joint associations between ETEs and cognitive function among older adults. Methods: A population (N = 2181) at an average age≥ 65 from Yiwu cohort in China was available for this study. Whole blood chromium (Cr), selenium (Se), manganese (Mn), and copper (Cu) concentrations were measured by inductively coupled plasma mass spectrometry (ICP-MS). Cognitive function was assessed using the Mini-Mental State Examination (MMSE), consisting of five specific cognitive domains: orientation, registry, attention and calculation, recall, and language and praxis. Linear regression, restricted cubic spline (RCS) analysis, and Bayesian kernel machine regression (BKMR) were used to analyze the individual and joint associations between ETEs and cognitive function. Results: The association between Cr and MMSE score presented an inverted-U shape (Q3 versus Q1: β = 0.774, 95 % CI: 0.297, 1.250; Q4 versus Q1: β = 0.481, 95 % CI: 0.006, 0.956); and Cr was especially associated with the registry, recall, and language and praxis. Per IQR (36.32 μg/L) increase of Se was positively associated with the MMSE score (β = 0.497, 95 % CI: 0.277, 0.717) and all five cognitive domains. The BKMR showed that the dose-response association between Se and cognitive function increased initially and then decreased with increasing Se concentration when fixed the other ETEs in median. ETEs mixture was positively associated with cognitive function, and Se (posterior inclusion probabilities, PIPs = 0.915) was the most important contributor within the ETEs mixture. Conclusions: The nonlinear association between Cr and cognitive function suggested further exploration of an appropriate concentration range for ETEs. A positive association between mixed ETEs and cognitive function is a reminder that their joint association should be considered. Further prospective studies or intervention studies are warranted to validate our findings in the future.http://www.sciencedirect.com/science/article/pii/S0147651323006188Cognitive functionEssential trace elementOlder adultsMixturesJoint association |
| spellingShingle | Yao-yao Lin Lin Meng Fan-jia Guo Xin-han Zhang Dan-dan Yang Xue-cheng Yao Ming-juan Jin Jian-bing Wang Meng-ling Tang Kun Chen Association between whole blood essential trace elements and cognitive function in older adults Ecotoxicology and Environmental Safety Cognitive function Essential trace element Older adults Mixtures Joint association |
| title | Association between whole blood essential trace elements and cognitive function in older adults |
| title_full | Association between whole blood essential trace elements and cognitive function in older adults |
| title_fullStr | Association between whole blood essential trace elements and cognitive function in older adults |
| title_full_unstemmed | Association between whole blood essential trace elements and cognitive function in older adults |
| title_short | Association between whole blood essential trace elements and cognitive function in older adults |
| title_sort | association between whole blood essential trace elements and cognitive function in older adults |
| topic | Cognitive function Essential trace element Older adults Mixtures Joint association |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323006188 |
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