Embryonic Blood-Cerebrospinal Fluid Barrier Formation and Function
During embryonic development and adult life, brain cavities and ventricles are filled with cerebrospinal fluid (CSF). CSF has attracted interest as an active signaling medium that regulates brain development, homeostasis and disease. CSF is a complex protein-rich fluid containing growth factors and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-10-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00343/full |
| _version_ | 1818304571339964416 |
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| author | David eBueno Maryam eParvas Ismaïl eHermelo Jordi eGarcia-Fernàndez |
| author_facet | David eBueno Maryam eParvas Ismaïl eHermelo Jordi eGarcia-Fernàndez |
| author_sort | David eBueno |
| collection | DOAJ |
| description | During embryonic development and adult life, brain cavities and ventricles are filled with cerebrospinal fluid (CSF). CSF has attracted interest as an active signaling medium that regulates brain development, homeostasis and disease. CSF is a complex protein-rich fluid containing growth factors and signaling molecules that regulate multiple cell functions in the central nervous system (CNS). The composition and substance concentrations of CSF are tightly controlled. In recent years, it has been demonstrated that embryonic CSF (eCSF) has a key function as a fluid pathway for delivering diffusible signals to the developing brain, thus contributing to the proliferation, differentiation and survival of neural progenitor cells, and to the expansion and patterning of the brain. From fetal stages through to adult life, CSF is primarily produced by the choroid plexus. The development and functional activities of the choroid plexus and other blood–brain barrier (BBB) systems in adults and fetuses have been extensively analyzed. However, eCSF production and control of its homeostasis in embryos, from the closure of the anterior neuropore when the brain cavities become physiologically sealed, to the formation of the functional fetal choroid plexus, has not been studied in as much depth and remains open to debate. This review brings together the existing literature, some of which is based on experiments conducted by our research group, concerning the formation and function of a temporary embryonic blood–CSF barrier in the context of the crucial roles played by the molecules in eCSF. |
| first_indexed | 2024-12-13T06:12:49Z |
| format | Article |
| id | doaj.art-0bc6a2a9be21443f895e897f669ccefc |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-13T06:12:49Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-0bc6a2a9be21443f895e897f669ccefc2022-12-21T23:57:02ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2014-10-01810.3389/fnins.2014.00343107323Embryonic Blood-Cerebrospinal Fluid Barrier Formation and FunctionDavid eBueno0Maryam eParvas1Ismaïl eHermelo2Jordi eGarcia-Fernàndez3University of BarcelonaUniversity of BarcelonaUniversity of BarcelonaUniversity of BarcelonaDuring embryonic development and adult life, brain cavities and ventricles are filled with cerebrospinal fluid (CSF). CSF has attracted interest as an active signaling medium that regulates brain development, homeostasis and disease. CSF is a complex protein-rich fluid containing growth factors and signaling molecules that regulate multiple cell functions in the central nervous system (CNS). The composition and substance concentrations of CSF are tightly controlled. In recent years, it has been demonstrated that embryonic CSF (eCSF) has a key function as a fluid pathway for delivering diffusible signals to the developing brain, thus contributing to the proliferation, differentiation and survival of neural progenitor cells, and to the expansion and patterning of the brain. From fetal stages through to adult life, CSF is primarily produced by the choroid plexus. The development and functional activities of the choroid plexus and other blood–brain barrier (BBB) systems in adults and fetuses have been extensively analyzed. However, eCSF production and control of its homeostasis in embryos, from the closure of the anterior neuropore when the brain cavities become physiologically sealed, to the formation of the functional fetal choroid plexus, has not been studied in as much depth and remains open to debate. This review brings together the existing literature, some of which is based on experiments conducted by our research group, concerning the formation and function of a temporary embryonic blood–CSF barrier in the context of the crucial roles played by the molecules in eCSF.http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00343/fullBrain Developmentneural progenitor cellsembryonic cerebrospinal fluidblood-eCSF barrierprimary neurogenesiscephalic vesicles |
| spellingShingle | David eBueno Maryam eParvas Ismaïl eHermelo Jordi eGarcia-Fernàndez Embryonic Blood-Cerebrospinal Fluid Barrier Formation and Function Frontiers in Neuroscience Brain Development neural progenitor cells embryonic cerebrospinal fluid blood-eCSF barrier primary neurogenesis cephalic vesicles |
| title | Embryonic Blood-Cerebrospinal Fluid Barrier Formation and Function |
| title_full | Embryonic Blood-Cerebrospinal Fluid Barrier Formation and Function |
| title_fullStr | Embryonic Blood-Cerebrospinal Fluid Barrier Formation and Function |
| title_full_unstemmed | Embryonic Blood-Cerebrospinal Fluid Barrier Formation and Function |
| title_short | Embryonic Blood-Cerebrospinal Fluid Barrier Formation and Function |
| title_sort | embryonic blood cerebrospinal fluid barrier formation and function |
| topic | Brain Development neural progenitor cells embryonic cerebrospinal fluid blood-eCSF barrier primary neurogenesis cephalic vesicles |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00343/full |
| work_keys_str_mv | AT davidebueno embryonicbloodcerebrospinalfluidbarrierformationandfunction AT maryameparvas embryonicbloodcerebrospinalfluidbarrierformationandfunction AT ismailehermelo embryonicbloodcerebrospinalfluidbarrierformationandfunction AT jordiegarciafernandez embryonicbloodcerebrospinalfluidbarrierformationandfunction |