The presence of senescent peripheral T-cells is negatively correlated to COVID-19 vaccine-induced immunity in cancer patients under 70 years of age

The presence of senescent peripheral T-cells is negatively correlated to COVID-19 vaccine-induced immunity in cancer patients under 70 years of age

PurposeCancer patients are at risk of severe COVID-19 infection, and vaccination is recommended. Nevertheless, we observe a failure of COVID-19 vaccines in this vulnerable population. We hypothesize that senescent peripheral T-cells alter COVID-19 vaccine-induced immunity.MethodsWe performed a monoc...

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Bibliographic Details
Main Authors: E. Orillard, L. Spehner, L. Mansi, A. Bouard, A. Falcoz, Q. Lepiller, E. Renaude, JR. Pallandre, A. Vienot, M. Kroemer, C. Borg
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
COVID-19, vaccination
predictive biomarker
cancer patient
T lymphocyte (T-cell)
senescence
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1160664/full

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