The Biological and Biomechanical Role of Transglutaminase-2 in the Tumour Microenvironment

The Biological and Biomechanical Role of Transglutaminase-2 in the Tumour Microenvironment

Transglutaminase-2 (TG2) is the most highly and ubiquitously expressed member of the transglutaminase enzyme family and is primarily involved in protein cross-linking. TG2 has been implicated in the development and progression of numerous cancers, with a direct role in multiple cellular processes an...

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Bibliographic Details
Main Authors: Robert Tempest, Sonia Guarnerio, Rawan Maani, Jamie Cooper, Nicholas Peake
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
transglutaminase
biomechanics
extracellular matrix
tumour microenvironment
Online Access:https://www.mdpi.com/2072-6694/13/11/2788

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