Role of androgen receptors in the development of hepatocellular carcinoma
Hepatocellular carcinoma （HCC） has emerged as a significant public health concern， posing a serious threat to the lives and health of residents in China. Furthermore， the incidence and mortality rates of HCC are notably higher in males than in females. Androgen receptors （AR） can contribute to the o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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Shanghai Preventive Medicine Association
2023-11-01
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| Series: | Shanghai yufang yixue |
| Subjects: | |
| Online Access: | http://www.sjpm.org.cn/cn/article/doi/10.19428/j.cnki.sjpm.2023.22926 |
| _version_ | 1797356721707941888 |
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| author | YANG Yitao GU Yu CHEN Ziyan LIU Wenbin CAO Guangwen |
| author_facet | YANG Yitao GU Yu CHEN Ziyan LIU Wenbin CAO Guangwen |
| author_sort | YANG Yitao |
| collection | DOAJ |
| description | Hepatocellular carcinoma （HCC） has emerged as a significant public health concern， posing a serious threat to the lives and health of residents in China. Furthermore， the incidence and mortality rates of HCC are notably higher in males than in females. Androgen receptors （AR） can contribute to the occurrence of male-specific cancers such as prostate cancer， suggesting a potential link to the increased susceptibility of males to HCC. Elucidating the cancer-promoting mechanism of AR and developing specific targeted interventions are effective ways to advance tertiary prevention of HCC and improve patient prognosis. This paper reviews the relevant evidence of AR’s role in promoting the occurrence and development of HCC， summarizes relevant mechanisms discovered to date， including promoting the stemness of HCC cells， altering the immune microenvironment， regulating key signaling pathways， inducing glycolysis in hepatocellular carcinoma， and synergizing with hepatitis B virus to promote HCC. Additionally， research directions for targeted interventions in HCC through AR-related signaling pathways are discussed. |
| first_indexed | 2024-03-08T14:31:41Z |
| format | Article |
| id | doaj.art-0bca6f39ea214aada85b24aec49dcb1e |
| institution | Directory Open Access Journal |
| issn | 1004-9231 |
| language | zho |
| last_indexed | 2024-03-08T14:31:41Z |
| publishDate | 2023-11-01 |
| publisher | Shanghai Preventive Medicine Association |
| record_format | Article |
| series | Shanghai yufang yixue |
| spelling | doaj.art-0bca6f39ea214aada85b24aec49dcb1e2024-01-12T09:31:20ZzhoShanghai Preventive Medicine AssociationShanghai yufang yixue1004-92312023-11-0135111157116110.19428/j.cnki.sjpm.2023.229261004-9231（2023）11-1157-05Role of androgen receptors in the development of hepatocellular carcinomaYANG YitaoGU YuCHEN ZiyanLIU WenbinCAO GuangwenHepatocellular carcinoma （HCC） has emerged as a significant public health concern， posing a serious threat to the lives and health of residents in China. Furthermore， the incidence and mortality rates of HCC are notably higher in males than in females. Androgen receptors （AR） can contribute to the occurrence of male-specific cancers such as prostate cancer， suggesting a potential link to the increased susceptibility of males to HCC. Elucidating the cancer-promoting mechanism of AR and developing specific targeted interventions are effective ways to advance tertiary prevention of HCC and improve patient prognosis. This paper reviews the relevant evidence of AR’s role in promoting the occurrence and development of HCC， summarizes relevant mechanisms discovered to date， including promoting the stemness of HCC cells， altering the immune microenvironment， regulating key signaling pathways， inducing glycolysis in hepatocellular carcinoma， and synergizing with hepatitis B virus to promote HCC. Additionally， research directions for targeted interventions in HCC through AR-related signaling pathways are discussed.http://www.sjpm.org.cn/cn/article/doi/10.19428/j.cnki.sjpm.2023.22926hepatocellular carcinomagender differenceandrogen receptormolecular mechanismhepatitis b virus |
| spellingShingle | YANG Yitao GU Yu CHEN Ziyan LIU Wenbin CAO Guangwen Role of androgen receptors in the development of hepatocellular carcinoma Shanghai yufang yixue hepatocellular carcinoma gender difference androgen receptor molecular mechanism hepatitis b virus |
| title | Role of androgen receptors in the development of hepatocellular carcinoma |
| title_full | Role of androgen receptors in the development of hepatocellular carcinoma |
| title_fullStr | Role of androgen receptors in the development of hepatocellular carcinoma |
| title_full_unstemmed | Role of androgen receptors in the development of hepatocellular carcinoma |
| title_short | Role of androgen receptors in the development of hepatocellular carcinoma |
| title_sort | role of androgen receptors in the development of hepatocellular carcinoma |
| topic | hepatocellular carcinoma gender difference androgen receptor molecular mechanism hepatitis b virus |
| url | http://www.sjpm.org.cn/cn/article/doi/10.19428/j.cnki.sjpm.2023.22926 |
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