Development and Validation of a HPLC–MS/MS Method to Measure Nifuroxazide and Its Application in Healthy and Glioblastoma-Bearing Mice

Development and Validation of a HPLC–MS/MS Method to Measure Nifuroxazide and Its Application in Healthy and Glioblastoma-Bearing Mice

Nifuroxazide (NAZ), a nitrofuran derivative used to treat diarrhea, has been recently shown to possess anticancer activity. However, its pharmacokinetic profile is poorly known. The pharmacokinetic profile of NAZ was thus investigated in mice using a newly developed method based on high-performance...

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Bibliographic Details
Main Authors: Tommaso Ceruti, Quintino Giorgio D’Alessandris, Roberta Frapolli, Jay Gopalakrishnan, Mariachiara Buccarelli, Marina Meroni, Liverana Lauretti, Lucia Ricci-Vitiani, Roberto Pallini, Massimo Zucchetti
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceutics
Subjects:
nifuroxazide
liquid chromatography–tandem mass spectrometry technique
pharmacokinetics
murine model
drug repositioning
Online Access:https://www.mdpi.com/1999-4923/14/10/2071

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