Low intensity extracorporeal shockwave Therapy shifts PDE5i nonresponders to responders
ABSTRACT To evaluate the efficiency of an energy density of 0.05mj/mm2 of low intensity extracorporeal shockwave therapy (Li-ESWT) on erectile dysfunction (ED) patients.A total of 45 ED patients met the inclusion criteria, including 7 PDE5i responders and 38 nonresponders. All the patients have alre...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2020-09-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382020000600934&tlng=en |
| _version_ | 1828131739140096000 |
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| author | Jiamin Wang Lianmin Luo Shankun Zhao Yangzhou Liu Zhiguo Zhu Zhigang Zhao |
| author_facet | Jiamin Wang Lianmin Luo Shankun Zhao Yangzhou Liu Zhiguo Zhu Zhigang Zhao |
| author_sort | Jiamin Wang |
| collection | DOAJ |
| description | ABSTRACT To evaluate the efficiency of an energy density of 0.05mj/mm2 of low intensity extracorporeal shockwave therapy (Li-ESWT) on erectile dysfunction (ED) patients.A total of 45 ED patients met the inclusion criteria, including 7 PDE5i responders and 38 nonresponders. All the patients have already been delivered 10000 shockwaves of total seven treatment points twice a week for 4 weeks. Simultaneously, questionnaires of International Index of Erectile Function-Erectile Function (IIEF-EF), Erectile Hard Score (EHS) and Minimal Clinical Important Differences (MCID) were evaluated for the efficiency and safety at 8th and 16th weeks.The changes in the IIEF-EF score by MCID suggested that Li-ESWT treatment was effective in 22 PDE5i nonresponders patients (58%) at 8th week. Then at 16th week the number of patients who were effectively treated increased to 27 (71%). Among PDE5i responders, 5 patients (71%) were effective base on MCID at 16th week. Among PDE5i nonresponders 22 patients (58%) achieved erection hard enough for vaginal penetration and increased to 27 (71%) patients at 16th week (EHS ≥3). Moreover, even 3 patients achieved EHS 4 in PDE5i nonresponders at 16th week. Among PDE5i responders, 4 of 7 patients reached EHS of 4 from EHS 3 at 16th week. Apart from this, Li-ESWT treatment was also effective in 9 patients (24%) in PDE5i nonresponders without follow-up PDE5i.Energy flux density (EFD) of 0.05 of Li-ESWT could improve the erectile function of ED patients with PDE5i response. In addition, EFD of 0.05 of Li-ESWT treatment could turn PDE5i nonresponders to responders. |
| first_indexed | 2024-04-11T16:52:50Z |
| format | Article |
| id | doaj.art-0bcaa16f4f4a46e1a652f7fed881de85 |
| institution | Directory Open Access Journal |
| issn | 1677-6119 |
| language | English |
| last_indexed | 2024-04-11T16:52:50Z |
| publishDate | 2020-09-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-0bcaa16f4f4a46e1a652f7fed881de852022-12-22T04:13:22ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-61192020-09-0146693494210.1590/s1677-5538.ibju.2019.0374Low intensity extracorporeal shockwave Therapy shifts PDE5i nonresponders to respondersJiamin WangLianmin LuoShankun Zhaohttps://orcid.org/0000-0002-0305-3912Yangzhou LiuZhiguo ZhuZhigang ZhaoABSTRACT To evaluate the efficiency of an energy density of 0.05mj/mm2 of low intensity extracorporeal shockwave therapy (Li-ESWT) on erectile dysfunction (ED) patients.A total of 45 ED patients met the inclusion criteria, including 7 PDE5i responders and 38 nonresponders. All the patients have already been delivered 10000 shockwaves of total seven treatment points twice a week for 4 weeks. Simultaneously, questionnaires of International Index of Erectile Function-Erectile Function (IIEF-EF), Erectile Hard Score (EHS) and Minimal Clinical Important Differences (MCID) were evaluated for the efficiency and safety at 8th and 16th weeks.The changes in the IIEF-EF score by MCID suggested that Li-ESWT treatment was effective in 22 PDE5i nonresponders patients (58%) at 8th week. Then at 16th week the number of patients who were effectively treated increased to 27 (71%). Among PDE5i responders, 5 patients (71%) were effective base on MCID at 16th week. Among PDE5i nonresponders 22 patients (58%) achieved erection hard enough for vaginal penetration and increased to 27 (71%) patients at 16th week (EHS ≥3). Moreover, even 3 patients achieved EHS 4 in PDE5i nonresponders at 16th week. Among PDE5i responders, 4 of 7 patients reached EHS of 4 from EHS 3 at 16th week. Apart from this, Li-ESWT treatment was also effective in 9 patients (24%) in PDE5i nonresponders without follow-up PDE5i.Energy flux density (EFD) of 0.05 of Li-ESWT could improve the erectile function of ED patients with PDE5i response. In addition, EFD of 0.05 of Li-ESWT treatment could turn PDE5i nonresponders to responders.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382020000600934&tlng=enErectile DysfunctionExtracorporeal Shockwave TherapyPharmaceutical Preparations |
| spellingShingle | Jiamin Wang Lianmin Luo Shankun Zhao Yangzhou Liu Zhiguo Zhu Zhigang Zhao Low intensity extracorporeal shockwave Therapy shifts PDE5i nonresponders to responders International Brazilian Journal of Urology Erectile Dysfunction Extracorporeal Shockwave Therapy Pharmaceutical Preparations |
| title | Low intensity extracorporeal shockwave Therapy shifts PDE5i nonresponders to responders |
| title_full | Low intensity extracorporeal shockwave Therapy shifts PDE5i nonresponders to responders |
| title_fullStr | Low intensity extracorporeal shockwave Therapy shifts PDE5i nonresponders to responders |
| title_full_unstemmed | Low intensity extracorporeal shockwave Therapy shifts PDE5i nonresponders to responders |
| title_short | Low intensity extracorporeal shockwave Therapy shifts PDE5i nonresponders to responders |
| title_sort | low intensity extracorporeal shockwave therapy shifts pde5i nonresponders to responders |
| topic | Erectile Dysfunction Extracorporeal Shockwave Therapy Pharmaceutical Preparations |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382020000600934&tlng=en |
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