The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition

The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition

Human patients carrying PAPP‐A2 inactivating mutations have low bone mineral density. The underlying mechanisms for this reduced calcification are poorly understood. Using a zebrafish model, we report that Papp-aa regulates bone calcification by promoting Ca2+-transporting epithelial cell (ionocyte)...

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Bibliographic Details
Main Authors: Chengdong Liu, Shuang Li, Pernille Rimmer Noer, Kasper Kjaer-Sorensen, Anna Karina Juhl, Allison Goldstein, Caihuan Ke, Claus Oxvig, Cunming Duan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
pappalysin
STC
IGFBP5
IGF signaling
zebrafish
Ca2+ deficiency
Online Access:https://elifesciences.org/articles/52322

Internet

https://elifesciences.org/articles/52322

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