Enterohemorrhagic Escherichia coli Effector Protein EspF Interacts With Host Protein ANXA6 and Triggers Myosin Light Chain Kinase (MLCK)-Dependent Tight Junction Dysregulation

Enterohemorrhagic Escherichia coli Effector Protein EspF Interacts With Host Protein ANXA6 and Triggers Myosin Light Chain Kinase (MLCK)-Dependent Tight Junction Dysregulation

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is an important foodborne pathogen that can cause bloody diarrhea and hemolytic uremic syndrome (HUS) in humans. EspF is one of the best-characterized effector proteins secreted from the type three secretion system to hijack host cell functions. Howe...

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Bibliographic Details
Main Authors: Ying Hua, Jiali Wu, Muqing Fu, Jinyue Liu, Xiaoxia Li, Bao Zhang, Wei Zhao, Chengsong Wan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
EHEC
O157: H7
EspF
protein–protein interaction
ANXA6
tight junction breakdown
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.613061/full

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