Human induced pluripotent stem cell engineering establishes a humanized mouse platform for pediatric low-grade glioma modeling

Human induced pluripotent stem cell engineering establishes a humanized mouse platform for pediatric low-grade glioma modeling

Abstract A major obstacle to identifying improved treatments for pediatric low-grade brain tumors (gliomas) is the inability to reproducibly generate human xenografts. To surmount this barrier, we leveraged human induced pluripotent stem cell (hiPSC) engineering to generate low-grade gliomas (LGGs)...

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Bibliographic Details
Main Authors: Corina Anastasaki, Jit Chatterjee, Olivia Cobb, Shilpa Sanapala, Suzanne M. Scheaffer, Amanda De Andrade Costa, Anna F. Wilson, Chloe M. Kernan, Ameera H. Zafar, Xia Ge, Joel R. Garbow, Fausto J. Rodriguez, David H. Gutmann
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Acta Neuropathologica Communications
Subjects:
Low-grade glioma
Pediatric brain tumor
Pilocytic astrocytoma
NF1
BRAF
Human induced pluripotent stem cells
Online Access:https://doi.org/10.1186/s40478-022-01428-2

Internet

https://doi.org/10.1186/s40478-022-01428-2

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