Aurora A's functions during mitotic exit: the Guess Who game
Until recently, the knowledge of Aurora A kinase functions during mitosis was limited to pre-metaphase events, particularly centrosome maturation, G2/M transition, and mitotic spindle assembly. However, an involvement of Aurora A in post-metaphase events was also suspected, but not clearly demonstra...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00290/full |
| _version_ | 1819126660593614848 |
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| author | David eReboutier Christelle eBenaud Claude ePrigent |
| author_facet | David eReboutier Christelle eBenaud Claude ePrigent |
| author_sort | David eReboutier |
| collection | DOAJ |
| description | Until recently, the knowledge of Aurora A kinase functions during mitosis was limited to pre-metaphase events, particularly centrosome maturation, G2/M transition, and mitotic spindle assembly. However, an involvement of Aurora A in post-metaphase events was also suspected, but not clearly demonstrated due to the technical difficulty to perform the appropriate experiments. Recent developments of both an analog specific version of Aurora A, and of small molecule inhibitors have led to the first demonstration that Aurora A is required for the early steps of cytokinesis. As in pre-metaphase, Aurora A plays diverse functions during anaphase, essentially participating in astral microtubules dynamics and central spindle assembly and functioning. The present review describes the experimental systems used to decipher new functions of Aurora A during late mitosis and situate these functions into the context of cytokinesis mechanisms. |
| first_indexed | 2024-12-22T07:59:34Z |
| format | Article |
| id | doaj.art-0bcf687d9d8540a3a1b5e6608c756f67 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-22T07:59:34Z |
| publishDate | 2015-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-0bcf687d9d8540a3a1b5e6608c756f672022-12-21T18:33:16ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2015-12-01510.3389/fonc.2015.00290170497Aurora A's functions during mitotic exit: the Guess Who gameDavid eReboutier0Christelle eBenaud1Claude ePrigent2Université Rennes 1Université Rennes 1Université Rennes 1Until recently, the knowledge of Aurora A kinase functions during mitosis was limited to pre-metaphase events, particularly centrosome maturation, G2/M transition, and mitotic spindle assembly. However, an involvement of Aurora A in post-metaphase events was also suspected, but not clearly demonstrated due to the technical difficulty to perform the appropriate experiments. Recent developments of both an analog specific version of Aurora A, and of small molecule inhibitors have led to the first demonstration that Aurora A is required for the early steps of cytokinesis. As in pre-metaphase, Aurora A plays diverse functions during anaphase, essentially participating in astral microtubules dynamics and central spindle assembly and functioning. The present review describes the experimental systems used to decipher new functions of Aurora A during late mitosis and situate these functions into the context of cytokinesis mechanisms.http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00290/fullCentrosomeCytokinesisMetaphaseMitosisAurora A kinase |
| spellingShingle | David eReboutier Christelle eBenaud Claude ePrigent Aurora A's functions during mitotic exit: the Guess Who game Frontiers in Oncology Centrosome Cytokinesis Metaphase Mitosis Aurora A kinase |
| title | Aurora A's functions during mitotic exit: the Guess Who game |
| title_full | Aurora A's functions during mitotic exit: the Guess Who game |
| title_fullStr | Aurora A's functions during mitotic exit: the Guess Who game |
| title_full_unstemmed | Aurora A's functions during mitotic exit: the Guess Who game |
| title_short | Aurora A's functions during mitotic exit: the Guess Who game |
| title_sort | aurora a 39 s functions during mitotic exit the guess who game |
| topic | Centrosome Cytokinesis Metaphase Mitosis Aurora A kinase |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00290/full |
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