Neutrophile-to-Lymphocyte Ratio (NLR) Identifies Patients with Coronavirus Infectious Disease 2019 (COVID-19) at High Risk for Deterioration and Mortality—A Retrospective, Monocentric Cohort Study
Among people infected with SARS-CoV-2, the determination of clinical features associated with poor outcome is essential to identify those at high risk of deterioration. Here, we aimed to investigate clinical phenotypes of patients hospitalized due to COVID-19 and to examine the predictive value of t...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/5/1109 |
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| author | Jutta Rose Flurina Suter Eva Furrer Ataman Sendoel Melina Stüssi-Helbling Lars C. Huber |
| author_facet | Jutta Rose Flurina Suter Eva Furrer Ataman Sendoel Melina Stüssi-Helbling Lars C. Huber |
| author_sort | Jutta Rose |
| collection | DOAJ |
| description | Among people infected with SARS-CoV-2, the determination of clinical features associated with poor outcome is essential to identify those at high risk of deterioration. Here, we aimed to investigate clinical phenotypes of patients hospitalized due to COVID-19 and to examine the predictive value of the neutrophil-to-lymphocyte ratio (NLR) in a representative patient collective of the Swiss population. We conducted a retrospective monocentriccohort study with patients hospitalized due to COVID-19 between 27 February and 31 December 2020. Data were analyzed descriptively, using the binary logistic regression model, proportional odds logistic regression model, competing risk analysis, and summary measure analysis. A total of 454 patients were included in our study. Dyspnea, elevated respiratory rate, low oxygen saturation at baseline, age, and presence of multiple comorbidities were associated with a more severe course of the disease. A high NLR at baseline was significantly associated with disease severity, unfavorable outcome, and mortality. In non-survivors, NLR further increased during hospital stay, whereas in survivors, NLR decreased. In conclusion, our data emphasize the importance of accurate history taking and clinical examination upon admission and confirm the role of baseline NLR as a surrogate marker for increased disease severity, unfavorable outcome, and mortality in patients hospitalized due to infection with SARS-CoV-2. |
| first_indexed | 2024-03-10T03:02:32Z |
| format | Article |
| id | doaj.art-0bd1a66ed4ba459789f0ad76a0b5110c |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T03:02:32Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-0bd1a66ed4ba459789f0ad76a0b5110c2023-11-23T10:39:29ZengMDPI AGDiagnostics2075-44182022-04-01125110910.3390/diagnostics12051109Neutrophile-to-Lymphocyte Ratio (NLR) Identifies Patients with Coronavirus Infectious Disease 2019 (COVID-19) at High Risk for Deterioration and Mortality—A Retrospective, Monocentric Cohort StudyJutta Rose0Flurina Suter1Eva Furrer2Ataman Sendoel3Melina Stüssi-Helbling4Lars C. Huber5Department of Internal Medicine, Clinic for Internal Medicine, City Hospital Zurich Triemli, 8063 Zurich, SwitzerlandMaster Program in Biostatistics, University of Zurich (UZH), 8006 Zurich, SwitzerlandDepartment Biostatistics, Institute for Epidemiology, Biostatistics and Prevention, University of Zurich (UZH), 8006 Zurich, SwitzerlandFaculty of Medicine, University of Zurich (UZH), 8006 Zurich, SwitzerlandDepartment of Internal Medicine, Clinic for Internal Medicine, City Hospital Zurich Triemli, 8063 Zurich, SwitzerlandDepartment of Internal Medicine, Clinic for Internal Medicine, City Hospital Zurich Triemli, 8063 Zurich, SwitzerlandAmong people infected with SARS-CoV-2, the determination of clinical features associated with poor outcome is essential to identify those at high risk of deterioration. Here, we aimed to investigate clinical phenotypes of patients hospitalized due to COVID-19 and to examine the predictive value of the neutrophil-to-lymphocyte ratio (NLR) in a representative patient collective of the Swiss population. We conducted a retrospective monocentriccohort study with patients hospitalized due to COVID-19 between 27 February and 31 December 2020. Data were analyzed descriptively, using the binary logistic regression model, proportional odds logistic regression model, competing risk analysis, and summary measure analysis. A total of 454 patients were included in our study. Dyspnea, elevated respiratory rate, low oxygen saturation at baseline, age, and presence of multiple comorbidities were associated with a more severe course of the disease. A high NLR at baseline was significantly associated with disease severity, unfavorable outcome, and mortality. In non-survivors, NLR further increased during hospital stay, whereas in survivors, NLR decreased. In conclusion, our data emphasize the importance of accurate history taking and clinical examination upon admission and confirm the role of baseline NLR as a surrogate marker for increased disease severity, unfavorable outcome, and mortality in patients hospitalized due to infection with SARS-CoV-2.https://www.mdpi.com/2075-4418/12/5/1109COVID-19SARS-CoV-2neutrophile-to-lymphocyte ratioNLRdisease severitymortality |
| spellingShingle | Jutta Rose Flurina Suter Eva Furrer Ataman Sendoel Melina Stüssi-Helbling Lars C. Huber Neutrophile-to-Lymphocyte Ratio (NLR) Identifies Patients with Coronavirus Infectious Disease 2019 (COVID-19) at High Risk for Deterioration and Mortality—A Retrospective, Monocentric Cohort Study Diagnostics COVID-19 SARS-CoV-2 neutrophile-to-lymphocyte ratio NLR disease severity mortality |
| title | Neutrophile-to-Lymphocyte Ratio (NLR) Identifies Patients with Coronavirus Infectious Disease 2019 (COVID-19) at High Risk for Deterioration and Mortality—A Retrospective, Monocentric Cohort Study |
| title_full | Neutrophile-to-Lymphocyte Ratio (NLR) Identifies Patients with Coronavirus Infectious Disease 2019 (COVID-19) at High Risk for Deterioration and Mortality—A Retrospective, Monocentric Cohort Study |
| title_fullStr | Neutrophile-to-Lymphocyte Ratio (NLR) Identifies Patients with Coronavirus Infectious Disease 2019 (COVID-19) at High Risk for Deterioration and Mortality—A Retrospective, Monocentric Cohort Study |
| title_full_unstemmed | Neutrophile-to-Lymphocyte Ratio (NLR) Identifies Patients with Coronavirus Infectious Disease 2019 (COVID-19) at High Risk for Deterioration and Mortality—A Retrospective, Monocentric Cohort Study |
| title_short | Neutrophile-to-Lymphocyte Ratio (NLR) Identifies Patients with Coronavirus Infectious Disease 2019 (COVID-19) at High Risk for Deterioration and Mortality—A Retrospective, Monocentric Cohort Study |
| title_sort | neutrophile to lymphocyte ratio nlr identifies patients with coronavirus infectious disease 2019 covid 19 at high risk for deterioration and mortality a retrospective monocentric cohort study |
| topic | COVID-19 SARS-CoV-2 neutrophile-to-lymphocyte ratio NLR disease severity mortality |
| url | https://www.mdpi.com/2075-4418/12/5/1109 |
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