Whole body Hyperthermia for the treatment of depression
Approximately 30% of patients with depressive episodes do not respond to conventional antidepressant medication or develop side effects. As a result, effective new treatments are urgently needed. Mood-enhancing effects of Whole body hyperthermia (WBH) have repeatedly been observed in various fields...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-04-01
|
| Series: | Journal of Affective Disorders Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666915323001014 |
| _version_ | 1797854442537615360 |
|---|---|
| author | Martin Schäfer Nils Auen Florian Rübener Rastan Rasouli Agata E. Ciesielska Laura Gebhardt Jessica Heinrich Heidemarie Haller Holger Cramer |
| author_facet | Martin Schäfer Nils Auen Florian Rübener Rastan Rasouli Agata E. Ciesielska Laura Gebhardt Jessica Heinrich Heidemarie Haller Holger Cramer |
| author_sort | Martin Schäfer |
| collection | DOAJ |
| description | Approximately 30% of patients with depressive episodes do not respond to conventional antidepressant medication or develop side effects. As a result, effective new treatments are urgently needed. Mood-enhancing effects of Whole body hyperthermia (WBH) have repeatedly been observed in various fields of medicine (e.g. rheumatology). A recent study by Janssen and colleagues (2016) with a randomized, double-blind and sham-controlled approach, was able to demonstrate a significant, rapid and partially lasting reduction of depressive symptoms in unmedicated patients with MDD following a WBH single session.Two randomized, double-blind, and (sham-) controlled clinical studies are currently conducted by our group in Essen (Germany). Overall, the studies focus on safety and tolerability data and the question whether WBH improves depressive symptoms in patients without any antidepressant treatment (HYPE I trial) or in patients with stable antidepressant treatment but non- or only partial response (HYPE II trial). In each subgroup, patients are randomized to either a verum group with two treatments with WBH in two weeks or a waiting group as controls. Beside response data, immune parameters in the serum of patients will be assessed.Preliminary results regarding safety and tolerability from the first 34 participants (N=16 treatment naive, N=18 non- or partly responder) showed, that WBH was well tolerated in most patients with or without antidepressant treatment. No serious side effects of WBH were observed that would have required further treatment. Overall, the risk for adverse effects during WBH was increased in case of somatic comorbidities.In summary, whole-body hyperthermia appears to be an interesting concept for a non-pharmacological treatment of perhaps subgroups like stress or immune induced depression. |
| first_indexed | 2024-04-09T20:07:12Z |
| format | Article |
| id | doaj.art-0bd1a8a70a6440ea86aa56d13ecd2a1b |
| institution | Directory Open Access Journal |
| issn | 2666-9153 |
| language | English |
| last_indexed | 2024-04-09T20:07:12Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Affective Disorders Reports |
| spelling | doaj.art-0bd1a8a70a6440ea86aa56d13ecd2a1b2023-04-01T08:52:01ZengElsevierJournal of Affective Disorders Reports2666-91532023-04-0112100562Whole body Hyperthermia for the treatment of depressionMartin Schäfer0Nils Auen1Florian Rübener2Rastan Rasouli3Agata E. Ciesielska4Laura Gebhardt5Jessica Heinrich6Heidemarie Haller7Holger Cramer8Department of Psychiatry, Psychotherapy, Psychosomatic and Addiction Medicine, Evang. Kliniken Essen-Mitte, Germany; Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité Univerity Medicine Berlin, Germany; Presenting authorDepartment of Psychiatry, Psychotherapy, Psychosomatic and Addiction Medicine, Evang. Kliniken Essen-Mitte, GermanyDepartment of Psychiatry, Psychotherapy, Psychosomatic and Addiction Medicine, Evang. Kliniken Essen-Mitte, GermanyDepartment of Psychiatry, Psychotherapy, Psychosomatic and Addiction Medicine, Evang. Kliniken Essen-Mitte, GermanyDepartment of Psychiatry, Psychotherapy, Psychosomatic and Addiction Medicine, Evang. Kliniken Essen-Mitte, GermanyDepartment of Psychiatry, Psychotherapy, Psychosomatic and Addiction Medicine, Evang. Kliniken Essen-Mitte, GermanyDepartment of Psychiatry, Psychotherapy, Psychosomatic and Addiction Medicine, Evang. Kliniken Essen-Mitte, GermanyKlinik für Naturheilkunde und Integrative Medizin, Evang. Kliniken Essen-Mitte, Medizinische Fakultät, Universität Duisburg-EssenKlinik für Naturheilkunde und Integrative Medizin, Evang. Kliniken Essen-Mitte, Medizinische Fakultät, Universität Duisburg-EssenApproximately 30% of patients with depressive episodes do not respond to conventional antidepressant medication or develop side effects. As a result, effective new treatments are urgently needed. Mood-enhancing effects of Whole body hyperthermia (WBH) have repeatedly been observed in various fields of medicine (e.g. rheumatology). A recent study by Janssen and colleagues (2016) with a randomized, double-blind and sham-controlled approach, was able to demonstrate a significant, rapid and partially lasting reduction of depressive symptoms in unmedicated patients with MDD following a WBH single session.Two randomized, double-blind, and (sham-) controlled clinical studies are currently conducted by our group in Essen (Germany). Overall, the studies focus on safety and tolerability data and the question whether WBH improves depressive symptoms in patients without any antidepressant treatment (HYPE I trial) or in patients with stable antidepressant treatment but non- or only partial response (HYPE II trial). In each subgroup, patients are randomized to either a verum group with two treatments with WBH in two weeks or a waiting group as controls. Beside response data, immune parameters in the serum of patients will be assessed.Preliminary results regarding safety and tolerability from the first 34 participants (N=16 treatment naive, N=18 non- or partly responder) showed, that WBH was well tolerated in most patients with or without antidepressant treatment. No serious side effects of WBH were observed that would have required further treatment. Overall, the risk for adverse effects during WBH was increased in case of somatic comorbidities.In summary, whole-body hyperthermia appears to be an interesting concept for a non-pharmacological treatment of perhaps subgroups like stress or immune induced depression.http://www.sciencedirect.com/science/article/pii/S2666915323001014 |
| spellingShingle | Martin Schäfer Nils Auen Florian Rübener Rastan Rasouli Agata E. Ciesielska Laura Gebhardt Jessica Heinrich Heidemarie Haller Holger Cramer Whole body Hyperthermia for the treatment of depression Journal of Affective Disorders Reports |
| title | Whole body Hyperthermia for the treatment of depression |
| title_full | Whole body Hyperthermia for the treatment of depression |
| title_fullStr | Whole body Hyperthermia for the treatment of depression |
| title_full_unstemmed | Whole body Hyperthermia for the treatment of depression |
| title_short | Whole body Hyperthermia for the treatment of depression |
| title_sort | whole body hyperthermia for the treatment of depression |
| url | http://www.sciencedirect.com/science/article/pii/S2666915323001014 |
| work_keys_str_mv | AT martinschafer wholebodyhyperthermiaforthetreatmentofdepression AT nilsauen wholebodyhyperthermiaforthetreatmentofdepression AT florianrubener wholebodyhyperthermiaforthetreatmentofdepression AT rastanrasouli wholebodyhyperthermiaforthetreatmentofdepression AT agataeciesielska wholebodyhyperthermiaforthetreatmentofdepression AT lauragebhardt wholebodyhyperthermiaforthetreatmentofdepression AT jessicaheinrich wholebodyhyperthermiaforthetreatmentofdepression AT heidemariehaller wholebodyhyperthermiaforthetreatmentofdepression AT holgercramer wholebodyhyperthermiaforthetreatmentofdepression |