GRP78 Inhibitor YUM70 Suppresses SARS-CoV-2 Viral Entry, Spike Protein Production and Ameliorates Lung Damage

GRP78 Inhibitor YUM70 Suppresses SARS-CoV-2 Viral Entry, Spike Protein Production and Ameliorates Lung Damage

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 pandemic, has given rise to many new variants with increased transmissibility and the ability to evade vaccine protection. The 78-kDa glucose-regulated protein (GRP78) is a major endoplasmic reticul...

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Bibliographic Details
Main Authors: Dat P. Ha, Woo-Jin Shin, Juan Carlos Hernandez, Nouri Neamati, Louis Dubeau, Keigo Machida, Amy S. Lee
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Viruses
Subjects:
GRP78
BiP
ER stress
COVID-19
SARS-CoV-2
variants
Online Access:https://www.mdpi.com/1999-4915/15/5/1118

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