Metabolomic Profiling of Different <i>Antrodia cinnamomea</i> Phenotypes
<i>Antrodia cinnamomea</i> (AC) is a precious medicinal fungus with numerous therapeutic benefits. Based on the color appearance of its fruiting bodies, AC can be divided into red AC (RAC), yellow AC (YAC), and white AC (WAC); however, the differences in their metabolomic profiles remain...
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MDPI AG
2023-01-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/9/1/97 |
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| author | Chun-Han Su Yun-Cheng Hsieh Jin-Yi Chng Ming-Nan Lai Lean-Teik Ng |
| author_facet | Chun-Han Su Yun-Cheng Hsieh Jin-Yi Chng Ming-Nan Lai Lean-Teik Ng |
| author_sort | Chun-Han Su |
| collection | DOAJ |
| description | <i>Antrodia cinnamomea</i> (AC) is a precious medicinal fungus with numerous therapeutic benefits. Based on the color appearance of its fruiting bodies, AC can be divided into red AC (RAC), yellow AC (YAC), and white AC (WAC); however, the differences in their metabolomic profiles remain unknown. This study aimed to analyze the metabolomic profiles of three different AC phenotypes and examine their relationship to the color appearance of fruiting bodies. The results showed that although RAC, YAC, and WAC appear to have a relatively similar profile of index triterpenoids, their total triterpenoid contents were significantly different. Among the annotated triterpenoids, many of them were highly present in RAC but not in YAC and WAC, and the relative contents of the four ergostanes (antcamphin F, antcamphin L, antcin B, and antcin K) and one lanostane (versisponic acid D) were found to be significantly different among AC phenotypes. The metabolomic profiles of the AC fruiting bodies demonstrated a total of 140 metabolites, and 41 of them were very different among AC phenotypes. This study indicates that red, yellow, and white AC can biosynthesize the diverse structures of triterpenoids, and RAC possesses a relatively higher contents of triterpenoids and diverse unannotated metabolites than YAC and WAC. |
| first_indexed | 2024-03-09T12:03:21Z |
| format | Article |
| id | doaj.art-0bd290198d944884ad87354790adc064 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T12:03:21Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-0bd290198d944884ad87354790adc0642023-11-30T23:00:17ZengMDPI AGJournal of Fungi2309-608X2023-01-01919710.3390/jof9010097Metabolomic Profiling of Different <i>Antrodia cinnamomea</i> PhenotypesChun-Han Su0Yun-Cheng Hsieh1Jin-Yi Chng2Ming-Nan Lai3Lean-Teik Ng4Department of Food Science, Fu Jen Catholic University, New Taipei City 242062, TaiwanDepartment of Agricultural Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, TaiwanDepartment of Agricultural Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, TaiwanKang Jian Biotech Co., Ltd., Nantou 54245, TaiwanDepartment of Agricultural Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan<i>Antrodia cinnamomea</i> (AC) is a precious medicinal fungus with numerous therapeutic benefits. Based on the color appearance of its fruiting bodies, AC can be divided into red AC (RAC), yellow AC (YAC), and white AC (WAC); however, the differences in their metabolomic profiles remain unknown. This study aimed to analyze the metabolomic profiles of three different AC phenotypes and examine their relationship to the color appearance of fruiting bodies. The results showed that although RAC, YAC, and WAC appear to have a relatively similar profile of index triterpenoids, their total triterpenoid contents were significantly different. Among the annotated triterpenoids, many of them were highly present in RAC but not in YAC and WAC, and the relative contents of the four ergostanes (antcamphin F, antcamphin L, antcin B, and antcin K) and one lanostane (versisponic acid D) were found to be significantly different among AC phenotypes. The metabolomic profiles of the AC fruiting bodies demonstrated a total of 140 metabolites, and 41 of them were very different among AC phenotypes. This study indicates that red, yellow, and white AC can biosynthesize the diverse structures of triterpenoids, and RAC possesses a relatively higher contents of triterpenoids and diverse unannotated metabolites than YAC and WAC.https://www.mdpi.com/2309-608X/9/1/97<i>Antrodia cinnamomea</i>phenotypesfruiting bodiesmetabolomicstriterpenoids |
| spellingShingle | Chun-Han Su Yun-Cheng Hsieh Jin-Yi Chng Ming-Nan Lai Lean-Teik Ng Metabolomic Profiling of Different <i>Antrodia cinnamomea</i> Phenotypes Journal of Fungi <i>Antrodia cinnamomea</i> phenotypes fruiting bodies metabolomics triterpenoids |
| title | Metabolomic Profiling of Different <i>Antrodia cinnamomea</i> Phenotypes |
| title_full | Metabolomic Profiling of Different <i>Antrodia cinnamomea</i> Phenotypes |
| title_fullStr | Metabolomic Profiling of Different <i>Antrodia cinnamomea</i> Phenotypes |
| title_full_unstemmed | Metabolomic Profiling of Different <i>Antrodia cinnamomea</i> Phenotypes |
| title_short | Metabolomic Profiling of Different <i>Antrodia cinnamomea</i> Phenotypes |
| title_sort | metabolomic profiling of different i antrodia cinnamomea i phenotypes |
| topic | <i>Antrodia cinnamomea</i> phenotypes fruiting bodies metabolomics triterpenoids |
| url | https://www.mdpi.com/2309-608X/9/1/97 |
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