Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles
Abstract Nanoparticle science is rapidly changing the landscape of various scientific fields and defining new technological platforms. This is perhaps even more evident in the field of nanomedicine whereby nanoparticles have been used as a tool for the treatment and diagnosis of many diseases. Howev...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-10-01
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| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s11671-018-2728-6 |
| _version_ | 1797709919901712384 |
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| author | Parisa Foroozandeh Azlan Abdul Aziz |
| author_facet | Parisa Foroozandeh Azlan Abdul Aziz |
| author_sort | Parisa Foroozandeh |
| collection | DOAJ |
| description | Abstract Nanoparticle science is rapidly changing the landscape of various scientific fields and defining new technological platforms. This is perhaps even more evident in the field of nanomedicine whereby nanoparticles have been used as a tool for the treatment and diagnosis of many diseases. However, despite the tremendous benefit conferred, common pitfalls of this technology is its potential short and long-term effects on the human body. To understand these issues, many scientific studies have been carried out. This review attempts to shed light on some of these studies and its outcomes. The topics that were examined in this review include the different possible uptake pathways of nanoparticles and intracellular trafficking routes. Additionally, the effect of physicochemical properties of nanoparticle such as size, shape, charge and surface chemistry in determining the mechanism of uptake and biological function of nanoparticles are also addressed. |
| first_indexed | 2024-03-12T06:44:49Z |
| format | Article |
| id | doaj.art-0bd2b2a054744680a912733de9b8f3db |
| institution | Directory Open Access Journal |
| issn | 1931-7573 1556-276X |
| language | English |
| last_indexed | 2024-03-12T06:44:49Z |
| publishDate | 2018-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-0bd2b2a054744680a912733de9b8f3db2023-09-03T00:36:45ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2018-10-0113111210.1186/s11671-018-2728-6Insight into Cellular Uptake and Intracellular Trafficking of NanoparticlesParisa Foroozandeh0Azlan Abdul Aziz1School of Physics, Universiti Sains MalaysiaSchool of Physics, Universiti Sains MalaysiaAbstract Nanoparticle science is rapidly changing the landscape of various scientific fields and defining new technological platforms. This is perhaps even more evident in the field of nanomedicine whereby nanoparticles have been used as a tool for the treatment and diagnosis of many diseases. However, despite the tremendous benefit conferred, common pitfalls of this technology is its potential short and long-term effects on the human body. To understand these issues, many scientific studies have been carried out. This review attempts to shed light on some of these studies and its outcomes. The topics that were examined in this review include the different possible uptake pathways of nanoparticles and intracellular trafficking routes. Additionally, the effect of physicochemical properties of nanoparticle such as size, shape, charge and surface chemistry in determining the mechanism of uptake and biological function of nanoparticles are also addressed.http://link.springer.com/article/10.1186/s11671-018-2728-6NanoparticlesCellular uptakeIntracellular traffickingNanomedicineCytotoxicity |
| spellingShingle | Parisa Foroozandeh Azlan Abdul Aziz Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles Nanoscale Research Letters Nanoparticles Cellular uptake Intracellular trafficking Nanomedicine Cytotoxicity |
| title | Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles |
| title_full | Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles |
| title_fullStr | Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles |
| title_full_unstemmed | Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles |
| title_short | Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles |
| title_sort | insight into cellular uptake and intracellular trafficking of nanoparticles |
| topic | Nanoparticles Cellular uptake Intracellular trafficking Nanomedicine Cytotoxicity |
| url | http://link.springer.com/article/10.1186/s11671-018-2728-6 |
| work_keys_str_mv | AT parisaforoozandeh insightintocellularuptakeandintracellulartraffickingofnanoparticles AT azlanabdulaziz insightintocellularuptakeandintracellulartraffickingofnanoparticles |