MMP9 SNP and MMP SNP–SNP interactions increase the risk for ischemic stroke in the Han Hakka population
Abstract Objectives To investigate the association of eight variants of four matrix metalloproteinase (MMP) genes with ischemic stroke (IS) and whether interactions among these single nucleotide polymorphisms (SNPs) increases the risk of IS. Methods Among 547 patients with ischemic stroke and 350 co...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-02-01
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| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.2473 |
| _version_ | 1797754631516848128 |
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| author | Daofeng Fan Chong Zheng Wenbao Wu Yinjuan Chen Dongping Chen Xiaohong Hu Chaoxiong Shen Mingsheng Chen Rongtong Li Yangui Chen |
| author_facet | Daofeng Fan Chong Zheng Wenbao Wu Yinjuan Chen Dongping Chen Xiaohong Hu Chaoxiong Shen Mingsheng Chen Rongtong Li Yangui Chen |
| author_sort | Daofeng Fan |
| collection | DOAJ |
| description | Abstract Objectives To investigate the association of eight variants of four matrix metalloproteinase (MMP) genes with ischemic stroke (IS) and whether interactions among these single nucleotide polymorphisms (SNPs) increases the risk of IS. Methods Among 547 patients with ischemic stroke and 350 controls, matrix‐assisted laser desorption/ionization time of flight mass spectrometry was used to examine eight variants arising from four different genes, including MMP‐1 (rs1799750), MMP‐2 (rs243865, rs2285053, rs2241145), MMP‐9 (rs17576), and MMP‐12 (rs660599, rs2276109, and rs652438). Gene–gene interactions were employed using generalized multifactor dimensionality reduction (GMDR) methods. Results The frequency of rs17576 was significantly higher in IS patients than in controls (p = .033). Logistic regression analysis revealed the AG and GG genotypes of rs17576 to be associated with a higher risk for IS, with the odds ratio and 95% confidence interval being 2.490 (1.251–4.959) and 2.494 (1.274–4.886), respectively. GMDR analysis showed a significant SNP‐SNP interaction between rs17576 and rs660599 (the testing balanced accuracy was 53.70% and cross‐validation consistency was 8/10, p = .0107). Logistic regression analysis showed the interaction between rs17576 and rs660599 to be an independent risk factor for IS with an odds ratio of 1.568 and a 95% confidence interval of 1.152–2.135. Conclusion An MMP‐9 rs17576 polymorphism is associated with increased IS risk in the Han Hakka population and interaction between MMP‐9 rs17576 and MMP‐12 rs660599 is associated with increased IS risk as well. |
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| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-12T17:36:17Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
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| series | Brain and Behavior |
| spelling | doaj.art-0bd32c677e1f4977ad46722a651c761a2023-08-04T10:55:38ZengWileyBrain and Behavior2162-32792022-02-01122n/an/a10.1002/brb3.2473MMP9 SNP and MMP SNP–SNP interactions increase the risk for ischemic stroke in the Han Hakka populationDaofeng Fan0Chong Zheng1Wenbao Wu2Yinjuan Chen3Dongping Chen4Xiaohong Hu5Chaoxiong Shen6Mingsheng Chen7Rongtong Li8Yangui Chen9Department of Neurology Longyan First Affiliated Hospital of Fujian Medical University, Longyan Fijian ChinaDepartment of Neurology Longyan First Affiliated Hospital of Fujian Medical University, Longyan Fijian ChinaDepartment of Acupuncture and Moxibustion Longyan First Affiliated Hospital of Fujian Medical University, Longyan Fijian ChinaDepartment of Neurology Longyan First Affiliated Hospital of Fujian Medical University, Longyan Fijian ChinaDepartment of Neurology Longyan First Affiliated Hospital of Fujian Medical University, Longyan Fijian ChinaDepartment of Neurology Longyan First Affiliated Hospital of Fujian Medical University, Longyan Fijian ChinaDepartment of Neurology Longyan First Affiliated Hospital of Fujian Medical University, Longyan Fijian ChinaDepartment of Neurology Longyan First Affiliated Hospital of Fujian Medical University, Longyan Fijian ChinaDepartment of Neurology Longyan First Affiliated Hospital of Fujian Medical University, Longyan Fijian ChinaDepartment of Neurology Longyan First Affiliated Hospital of Fujian Medical University, Longyan Fijian ChinaAbstract Objectives To investigate the association of eight variants of four matrix metalloproteinase (MMP) genes with ischemic stroke (IS) and whether interactions among these single nucleotide polymorphisms (SNPs) increases the risk of IS. Methods Among 547 patients with ischemic stroke and 350 controls, matrix‐assisted laser desorption/ionization time of flight mass spectrometry was used to examine eight variants arising from four different genes, including MMP‐1 (rs1799750), MMP‐2 (rs243865, rs2285053, rs2241145), MMP‐9 (rs17576), and MMP‐12 (rs660599, rs2276109, and rs652438). Gene–gene interactions were employed using generalized multifactor dimensionality reduction (GMDR) methods. Results The frequency of rs17576 was significantly higher in IS patients than in controls (p = .033). Logistic regression analysis revealed the AG and GG genotypes of rs17576 to be associated with a higher risk for IS, with the odds ratio and 95% confidence interval being 2.490 (1.251–4.959) and 2.494 (1.274–4.886), respectively. GMDR analysis showed a significant SNP‐SNP interaction between rs17576 and rs660599 (the testing balanced accuracy was 53.70% and cross‐validation consistency was 8/10, p = .0107). Logistic regression analysis showed the interaction between rs17576 and rs660599 to be an independent risk factor for IS with an odds ratio of 1.568 and a 95% confidence interval of 1.152–2.135. Conclusion An MMP‐9 rs17576 polymorphism is associated with increased IS risk in the Han Hakka population and interaction between MMP‐9 rs17576 and MMP‐12 rs660599 is associated with increased IS risk as well.https://doi.org/10.1002/brb3.2473arteriosclerosisGMDRischemic strokeMMP‐12MMP‐9polymorphism |
| spellingShingle | Daofeng Fan Chong Zheng Wenbao Wu Yinjuan Chen Dongping Chen Xiaohong Hu Chaoxiong Shen Mingsheng Chen Rongtong Li Yangui Chen MMP9 SNP and MMP SNP–SNP interactions increase the risk for ischemic stroke in the Han Hakka population Brain and Behavior arteriosclerosis GMDR ischemic stroke MMP‐12 MMP‐9 polymorphism |
| title | MMP9 SNP and MMP SNP–SNP interactions increase the risk for ischemic stroke in the Han Hakka population |
| title_full | MMP9 SNP and MMP SNP–SNP interactions increase the risk for ischemic stroke in the Han Hakka population |
| title_fullStr | MMP9 SNP and MMP SNP–SNP interactions increase the risk for ischemic stroke in the Han Hakka population |
| title_full_unstemmed | MMP9 SNP and MMP SNP–SNP interactions increase the risk for ischemic stroke in the Han Hakka population |
| title_short | MMP9 SNP and MMP SNP–SNP interactions increase the risk for ischemic stroke in the Han Hakka population |
| title_sort | mmp9 snp and mmp snp snp interactions increase the risk for ischemic stroke in the han hakka population |
| topic | arteriosclerosis GMDR ischemic stroke MMP‐12 MMP‐9 polymorphism |
| url | https://doi.org/10.1002/brb3.2473 |
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