Microtissue Culture Provides Clarity on the Relative Chondrogenic and Hypertrophic Response of Bone-Marrow-Derived Stromal Cells to TGF-β1, BMP-2, and GDF-5

Microtissue Culture Provides Clarity on the Relative Chondrogenic and Hypertrophic Response of Bone-Marrow-Derived Stromal Cells to TGF-β1, BMP-2, and GDF-5

Chondrogenic induction of bone-marrow-derived stromal cells (BMSCs) is typically accomplished with medium supplemented with growth factors (GF) from the transforming growth factor-beta (TGF-β)/bone morphogenetic factor (BMP) superfamily. In a previous study, we demonstrated that brief (1–3 days) sti...

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Bibliographic Details
Main Authors: Rose Ann G. Franco, Eamonn McKenna, Md. Shafiullah Shajib, Bianca Guillesser, Pamela G. Robey, Ross W. Crawford, Michael R. Doran, Kathryn Futrega
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
TGF-β1
BMP-2
GDF-5
BMSC chondrogenesis
hypertrophy
Microwell-mesh
Online Access:https://www.mdpi.com/2073-4409/13/1/37

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