Chagas Disease: From Discovery to a Worldwide Health Problem
Carlos Chagas discovered American trypanosomiasis, also named Chagas disease (CD) in his honor, just over a century ago. He described the clinical aspects of the disease, characterized by its etiological agent (Trypanosoma cruzi) and identified its insect vector. Initially, CD occurred only in Latin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpubh.2019.00166/full |
| _version_ | 1818291496830369792 |
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| author | Kárita Cláudia Freitas Lidani Fabiana Antunes Andrade Lorena Bavia Flávia Silva Damasceno Marcia Holsbach Beltrame Iara J. Messias-Reason Thaisa Lucas Sandri Thaisa Lucas Sandri |
| author_facet | Kárita Cláudia Freitas Lidani Fabiana Antunes Andrade Lorena Bavia Flávia Silva Damasceno Marcia Holsbach Beltrame Iara J. Messias-Reason Thaisa Lucas Sandri Thaisa Lucas Sandri |
| author_sort | Kárita Cláudia Freitas Lidani |
| collection | DOAJ |
| description | Carlos Chagas discovered American trypanosomiasis, also named Chagas disease (CD) in his honor, just over a century ago. He described the clinical aspects of the disease, characterized by its etiological agent (Trypanosoma cruzi) and identified its insect vector. Initially, CD occurred only in Latin America and was considered a silent and poorly visible disease. More recently, CD became a neglected worldwide disease with a high morbimortality rate and substantial social impact, emerging as a significant public health threat. In this context, it is crucial to better understand better the epidemiological scenarios of CD and its transmission dynamics, involving people infected and at risk of infection, diversity of the parasite, vector species, and T. cruzi reservoirs. Although efforts have been made by endemic and non-endemic countries to control, treat, and interrupt disease transmission, the cure or complete eradication of CD are still topics of great concern and require global attention. Considering the current scenario of CD, also affecting non-endemic places such as Canada, USA, Europe, Australia, and Japan, in this review we aim to describe the spread of CD cases worldwide since its discovery until it has become a global public health concern. |
| first_indexed | 2024-12-13T02:45:00Z |
| format | Article |
| id | doaj.art-0bd659d7a58746b5961d97c1fd0532c8 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-13T02:45:00Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-0bd659d7a58746b5961d97c1fd0532c82022-12-22T00:02:12ZengFrontiers Media S.A.Frontiers in Public Health2296-25652019-07-01710.3389/fpubh.2019.00166458711Chagas Disease: From Discovery to a Worldwide Health ProblemKárita Cláudia Freitas Lidani0Fabiana Antunes Andrade1Lorena Bavia2Flávia Silva Damasceno3Marcia Holsbach Beltrame4Iara J. Messias-Reason5Thaisa Lucas Sandri6Thaisa Lucas Sandri7Laboratory of Molecular Immunopathology, Clinical Hospital, Federal University of Paraná, Curitiba, BrazilLaboratory of Molecular Immunopathology, Clinical Hospital, Federal University of Paraná, Curitiba, BrazilLaboratory of Molecular Immunopathology, Clinical Hospital, Federal University of Paraná, Curitiba, BrazilLaboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute for Biomedical Sciences, University of São Paulo, São Paulo, BrazilLaboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paraná, Curitiba, BrazilLaboratory of Molecular Immunopathology, Clinical Hospital, Federal University of Paraná, Curitiba, BrazilLaboratory of Molecular Immunopathology, Clinical Hospital, Federal University of Paraná, Curitiba, BrazilInstitute of Tropical Medicine, University of Tübingen, Tübingen, GermanyCarlos Chagas discovered American trypanosomiasis, also named Chagas disease (CD) in his honor, just over a century ago. He described the clinical aspects of the disease, characterized by its etiological agent (Trypanosoma cruzi) and identified its insect vector. Initially, CD occurred only in Latin America and was considered a silent and poorly visible disease. More recently, CD became a neglected worldwide disease with a high morbimortality rate and substantial social impact, emerging as a significant public health threat. In this context, it is crucial to better understand better the epidemiological scenarios of CD and its transmission dynamics, involving people infected and at risk of infection, diversity of the parasite, vector species, and T. cruzi reservoirs. Although efforts have been made by endemic and non-endemic countries to control, treat, and interrupt disease transmission, the cure or complete eradication of CD are still topics of great concern and require global attention. Considering the current scenario of CD, also affecting non-endemic places such as Canada, USA, Europe, Australia, and Japan, in this review we aim to describe the spread of CD cases worldwide since its discovery until it has become a global public health concern.https://www.frontiersin.org/article/10.3389/fpubh.2019.00166/fullChagas diseaseepidemiologyTrypanosoma cruziChagas cardiomyopathyneglected disease |
| spellingShingle | Kárita Cláudia Freitas Lidani Fabiana Antunes Andrade Lorena Bavia Flávia Silva Damasceno Marcia Holsbach Beltrame Iara J. Messias-Reason Thaisa Lucas Sandri Thaisa Lucas Sandri Chagas Disease: From Discovery to a Worldwide Health Problem Frontiers in Public Health Chagas disease epidemiology Trypanosoma cruzi Chagas cardiomyopathy neglected disease |
| title | Chagas Disease: From Discovery to a Worldwide Health Problem |
| title_full | Chagas Disease: From Discovery to a Worldwide Health Problem |
| title_fullStr | Chagas Disease: From Discovery to a Worldwide Health Problem |
| title_full_unstemmed | Chagas Disease: From Discovery to a Worldwide Health Problem |
| title_short | Chagas Disease: From Discovery to a Worldwide Health Problem |
| title_sort | chagas disease from discovery to a worldwide health problem |
| topic | Chagas disease epidemiology Trypanosoma cruzi Chagas cardiomyopathy neglected disease |
| url | https://www.frontiersin.org/article/10.3389/fpubh.2019.00166/full |
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