Biomechanical analysis of bone mesoscopic structure and mechanical properties of vertebral endplates of degenerated intervertebral discs in rabbits
In previous studies of disc degeneration, the structural and mechanical properties of the endplate were often neglected. In this paper, the station legislation was used to construct an animal model of minor trauma disc degeneration, and the mechanism of disc degeneration was further investigated by...
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Elsevier
2024-06-01
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| Series: | Medicine in Novel Technology and Devices |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590093524000146 |
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| author | Bingying Zhao Yuan Guo Xushu Zhang Yibo Zhao Bin Zhao Ming Zhang |
| author_facet | Bingying Zhao Yuan Guo Xushu Zhang Yibo Zhao Bin Zhao Ming Zhang |
| author_sort | Bingying Zhao |
| collection | DOAJ |
| description | In previous studies of disc degeneration, the structural and mechanical properties of the endplate were often neglected. In this paper, the station legislation was used to construct an animal model of minor trauma disc degeneration, and the mechanism of disc degeneration was further investigated by observing the changes of mesoscopic structure and developing the mechanical properties of endplate bone.Twenty-eight 6-month-old Japanese white rabbits were divided into two groups: control group and experimental group. An animal model of intervertebral disc degeneration was established by upright experiment in the experimental group. The bone mesoscopic structures in different areas of each endplate were observed by histological and imaging methods, and the mechanical properties of the endplates were measured by indentation method. The two groups of data were compared by one-way ANOVA.After the experimental animals stood for 17 weeks, The experimental group showed the characteristics of early disc degeneration. The microstructure of the degenerative group showed that the end plate mineralization degree was higher, the bone mass was larger, and the number and thickness of bone trabeculae were larger. The results of indentation test showed that the mechanical properties of the degeneration group were enhanced, and the lower endplate was obviously enhanced.We successfully established a model of human disc degeneration with non invasive trauma and more consistent with the process of human disc degeneration through the standing experiment. In the experimental group, the internal structure of the endplate was dense and pore distance was reduced. The change of bone mesoscopic structure further affects the endplate, resulting in the enhancement of the mechanical properties of the endplate after intervertebral disc degeneration. The reduction of the pore distance and the narrowing of the internal channel structure of the endplate also hinder the nutrition supply of the intervertebral disc, which may be the key reason affecting the degeneration of the intervertebral disc. A biomechanical method for investigating the mechanism of intervertebral disc degeneration can be provided in this paper. |
| first_indexed | 2024-04-24T11:36:56Z |
| format | Article |
| id | doaj.art-0bd76df283ea44d693533910b05b358e |
| institution | Directory Open Access Journal |
| issn | 2590-0935 |
| language | English |
| last_indexed | 2024-04-24T11:36:56Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Novel Technology and Devices |
| spelling | doaj.art-0bd76df283ea44d693533910b05b358e2024-04-10T04:29:23ZengElsevierMedicine in Novel Technology and Devices2590-09352024-06-0122100298Biomechanical analysis of bone mesoscopic structure and mechanical properties of vertebral endplates of degenerated intervertebral discs in rabbitsBingying Zhao0Yuan Guo1Xushu Zhang2Yibo Zhao3Bin Zhao4Ming Zhang5College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, ChinaCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China; Corresponding author.College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, ChinaThe Second Hospital of Shanxi Medical University, Taiyuan City, 030001, China; Corresponding author.The Second Hospital of Shanxi Medical University, Taiyuan City, 030001, ChinaDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, 999077, China; Corresponding author.In previous studies of disc degeneration, the structural and mechanical properties of the endplate were often neglected. In this paper, the station legislation was used to construct an animal model of minor trauma disc degeneration, and the mechanism of disc degeneration was further investigated by observing the changes of mesoscopic structure and developing the mechanical properties of endplate bone.Twenty-eight 6-month-old Japanese white rabbits were divided into two groups: control group and experimental group. An animal model of intervertebral disc degeneration was established by upright experiment in the experimental group. The bone mesoscopic structures in different areas of each endplate were observed by histological and imaging methods, and the mechanical properties of the endplates were measured by indentation method. The two groups of data were compared by one-way ANOVA.After the experimental animals stood for 17 weeks, The experimental group showed the characteristics of early disc degeneration. The microstructure of the degenerative group showed that the end plate mineralization degree was higher, the bone mass was larger, and the number and thickness of bone trabeculae were larger. The results of indentation test showed that the mechanical properties of the degeneration group were enhanced, and the lower endplate was obviously enhanced.We successfully established a model of human disc degeneration with non invasive trauma and more consistent with the process of human disc degeneration through the standing experiment. In the experimental group, the internal structure of the endplate was dense and pore distance was reduced. The change of bone mesoscopic structure further affects the endplate, resulting in the enhancement of the mechanical properties of the endplate after intervertebral disc degeneration. The reduction of the pore distance and the narrowing of the internal channel structure of the endplate also hinder the nutrition supply of the intervertebral disc, which may be the key reason affecting the degeneration of the intervertebral disc. A biomechanical method for investigating the mechanism of intervertebral disc degeneration can be provided in this paper.http://www.sciencedirect.com/science/article/pii/S2590093524000146Vertebral endplateBiomechanicsIntervertebral disc degeneration modelMechanical propertiesMesoscopic structure |
| spellingShingle | Bingying Zhao Yuan Guo Xushu Zhang Yibo Zhao Bin Zhao Ming Zhang Biomechanical analysis of bone mesoscopic structure and mechanical properties of vertebral endplates of degenerated intervertebral discs in rabbits Medicine in Novel Technology and Devices Vertebral endplate Biomechanics Intervertebral disc degeneration model Mechanical properties Mesoscopic structure |
| title | Biomechanical analysis of bone mesoscopic structure and mechanical properties of vertebral endplates of degenerated intervertebral discs in rabbits |
| title_full | Biomechanical analysis of bone mesoscopic structure and mechanical properties of vertebral endplates of degenerated intervertebral discs in rabbits |
| title_fullStr | Biomechanical analysis of bone mesoscopic structure and mechanical properties of vertebral endplates of degenerated intervertebral discs in rabbits |
| title_full_unstemmed | Biomechanical analysis of bone mesoscopic structure and mechanical properties of vertebral endplates of degenerated intervertebral discs in rabbits |
| title_short | Biomechanical analysis of bone mesoscopic structure and mechanical properties of vertebral endplates of degenerated intervertebral discs in rabbits |
| title_sort | biomechanical analysis of bone mesoscopic structure and mechanical properties of vertebral endplates of degenerated intervertebral discs in rabbits |
| topic | Vertebral endplate Biomechanics Intervertebral disc degeneration model Mechanical properties Mesoscopic structure |
| url | http://www.sciencedirect.com/science/article/pii/S2590093524000146 |
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