The association between sonographic enthesitis and radiographic damage in psoriatic arthritis
Abstract Background To examine the association between sonographic enthesitis and the severity of radiographic features of damage in the peripheral and axial joints in psoriatic arthritis (PsA). Methods A cross-sectional analysis was conducted in patients with PsA. The MAdrid Sonography Enthesitis I...
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13075-017-1399-5 |
| _version_ | 1818198294019440640 |
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| author | Ari Polachek Richard Cook Vinod Chandran Dafna D. Gladman Lihi Eder |
| author_facet | Ari Polachek Richard Cook Vinod Chandran Dafna D. Gladman Lihi Eder |
| author_sort | Ari Polachek |
| collection | DOAJ |
| description | Abstract Background To examine the association between sonographic enthesitis and the severity of radiographic features of damage in the peripheral and axial joints in psoriatic arthritis (PsA). Methods A cross-sectional analysis was conducted in patients with PsA. The MAdrid Sonography Enthesitis Index (MASEI) scoring system was used to quantify the extent of sonographic entheseal abnormalities. Radiographic damage in the peripheral joints and spine was assessed by the modified Steinbrocker score (mSS), Modified New York Criteria for sacroiliitis, and the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). The association between MASEI and the extent of radiographic damage was assessed using negative binomial and logistic regression. The results were expressed in terms of the regression coefficient estimates and their exponentiated values (eβ) or odds ratios (OR), and 95% confidence intervals (CI). Results Two hundred and twenty three patients were analyzed; 58% were males, with mean ± SD age of 55.9 ± 12.9 years and PsA duration of 16.7 ± 12.4 years. Regression analyses yielded an association between higher MASEI scores (10 units increase) and peripheral joint damage including mSS (eβ = 1.42, 95% CI: 1.15, 1.72), joint ankylosis (OR = 1.93, 95% CI: 1.37, 2.72), arthritis mutilans (OR = 1.77, 95% CI: 1.23, 2.54), and periostitis (OR = 1.41, 95% CI: 1.08, 1.84). Similarly, an association was found between higher MASEI scores and axial damage as measured by mSASSS (eβ = 2.18, 95% CI: 1.16, 4.09) and sacroiliitis (OR = 1.33, 95% CI: 1.03, 1.72). Conclusions The severity of sonographic enthesitis is a potential marker of radiographic peripheral and axial joint damage in PsA. |
| first_indexed | 2024-12-12T02:03:35Z |
| format | Article |
| id | doaj.art-0bd880feb6df417e9a0a5717ad063d47 |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-12-12T02:03:35Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-0bd880feb6df417e9a0a5717ad063d472022-12-22T00:42:07ZengBMCArthritis Research & Therapy1478-63622017-08-011911810.1186/s13075-017-1399-5The association between sonographic enthesitis and radiographic damage in psoriatic arthritisAri Polachek0Richard Cook1Vinod Chandran2Dafna D. Gladman3Lihi Eder4Centre for Prognostic Studies in the Rheumatic Diseases, Toronto Western Hospital, University of TorontoDepartment of Statistics and Actuarial Science, University of WaterlooDepartment of Medicine and Laboratory Medicine, Institute of Medical Science, University of TorontoCenter for Prognostic Studies in the Rheumatic Diseases, Toronto Western Hospital, University of TorontoDepartment of Medicine, University of Toronto, Women’s College Research Institute, Women’s College HospitalAbstract Background To examine the association between sonographic enthesitis and the severity of radiographic features of damage in the peripheral and axial joints in psoriatic arthritis (PsA). Methods A cross-sectional analysis was conducted in patients with PsA. The MAdrid Sonography Enthesitis Index (MASEI) scoring system was used to quantify the extent of sonographic entheseal abnormalities. Radiographic damage in the peripheral joints and spine was assessed by the modified Steinbrocker score (mSS), Modified New York Criteria for sacroiliitis, and the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). The association between MASEI and the extent of radiographic damage was assessed using negative binomial and logistic regression. The results were expressed in terms of the regression coefficient estimates and their exponentiated values (eβ) or odds ratios (OR), and 95% confidence intervals (CI). Results Two hundred and twenty three patients were analyzed; 58% were males, with mean ± SD age of 55.9 ± 12.9 years and PsA duration of 16.7 ± 12.4 years. Regression analyses yielded an association between higher MASEI scores (10 units increase) and peripheral joint damage including mSS (eβ = 1.42, 95% CI: 1.15, 1.72), joint ankylosis (OR = 1.93, 95% CI: 1.37, 2.72), arthritis mutilans (OR = 1.77, 95% CI: 1.23, 2.54), and periostitis (OR = 1.41, 95% CI: 1.08, 1.84). Similarly, an association was found between higher MASEI scores and axial damage as measured by mSASSS (eβ = 2.18, 95% CI: 1.16, 4.09) and sacroiliitis (OR = 1.33, 95% CI: 1.03, 1.72). Conclusions The severity of sonographic enthesitis is a potential marker of radiographic peripheral and axial joint damage in PsA.http://link.springer.com/article/10.1186/s13075-017-1399-5SpondyloarthritisPathogenesisUltrasoundSteinbrockerSacroiliitisSpondylitis |
| spellingShingle | Ari Polachek Richard Cook Vinod Chandran Dafna D. Gladman Lihi Eder The association between sonographic enthesitis and radiographic damage in psoriatic arthritis Arthritis Research & Therapy Spondyloarthritis Pathogenesis Ultrasound Steinbrocker Sacroiliitis Spondylitis |
| title | The association between sonographic enthesitis and radiographic damage in psoriatic arthritis |
| title_full | The association between sonographic enthesitis and radiographic damage in psoriatic arthritis |
| title_fullStr | The association between sonographic enthesitis and radiographic damage in psoriatic arthritis |
| title_full_unstemmed | The association between sonographic enthesitis and radiographic damage in psoriatic arthritis |
| title_short | The association between sonographic enthesitis and radiographic damage in psoriatic arthritis |
| title_sort | association between sonographic enthesitis and radiographic damage in psoriatic arthritis |
| topic | Spondyloarthritis Pathogenesis Ultrasound Steinbrocker Sacroiliitis Spondylitis |
| url | http://link.springer.com/article/10.1186/s13075-017-1399-5 |
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