Cadherin-dependent cell morphology in an epithelium: constructing a quantitative dynamical model.
Cells in the Drosophila retina have well-defined morphologies that are attained during tissue morphogenesis. We present a computer simulation of the epithelial tissue in which the global interfacial energy between cells is minimized. Experimental data for both normal cells and mutant cells either la...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-07-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC3140965?pdf=render |
| _version_ | 1811281450347003904 |
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| author | Ian M Gemp Richard W Carthew Sascha Hilgenfeldt |
| author_facet | Ian M Gemp Richard W Carthew Sascha Hilgenfeldt |
| author_sort | Ian M Gemp |
| collection | DOAJ |
| description | Cells in the Drosophila retina have well-defined morphologies that are attained during tissue morphogenesis. We present a computer simulation of the epithelial tissue in which the global interfacial energy between cells is minimized. Experimental data for both normal cells and mutant cells either lacking or misexpressing the adhesion protein N-cadherin can be explained by a simple model incorporating salient features of morphogenesis that include the timing of N-cadherin expression in cells and its temporal relationship to the remodeling of cell-cell contacts. The simulations reproduce the geometries of wild-type and mutant cells, distinguish features of cadherin dynamics, and emphasize the importance of adhesion protein biogenesis and its timing with respect to cell remodeling. The simulations also indicate that N-cadherin protein is recycled from inactive interfaces to active interfaces, thereby modulating adhesion strengths between cells. |
| first_indexed | 2024-04-13T01:32:46Z |
| format | Article |
| id | doaj.art-0bd98ba0fa924adca1889d60b38326aa |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-04-13T01:32:46Z |
| publishDate | 2011-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-0bd98ba0fa924adca1889d60b38326aa2022-12-22T03:08:27ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582011-07-0177e100211510.1371/journal.pcbi.1002115Cadherin-dependent cell morphology in an epithelium: constructing a quantitative dynamical model.Ian M GempRichard W CarthewSascha HilgenfeldtCells in the Drosophila retina have well-defined morphologies that are attained during tissue morphogenesis. We present a computer simulation of the epithelial tissue in which the global interfacial energy between cells is minimized. Experimental data for both normal cells and mutant cells either lacking or misexpressing the adhesion protein N-cadherin can be explained by a simple model incorporating salient features of morphogenesis that include the timing of N-cadherin expression in cells and its temporal relationship to the remodeling of cell-cell contacts. The simulations reproduce the geometries of wild-type and mutant cells, distinguish features of cadherin dynamics, and emphasize the importance of adhesion protein biogenesis and its timing with respect to cell remodeling. The simulations also indicate that N-cadherin protein is recycled from inactive interfaces to active interfaces, thereby modulating adhesion strengths between cells.http://europepmc.org/articles/PMC3140965?pdf=render |
| spellingShingle | Ian M Gemp Richard W Carthew Sascha Hilgenfeldt Cadherin-dependent cell morphology in an epithelium: constructing a quantitative dynamical model. PLoS Computational Biology |
| title | Cadherin-dependent cell morphology in an epithelium: constructing a quantitative dynamical model. |
| title_full | Cadherin-dependent cell morphology in an epithelium: constructing a quantitative dynamical model. |
| title_fullStr | Cadherin-dependent cell morphology in an epithelium: constructing a quantitative dynamical model. |
| title_full_unstemmed | Cadherin-dependent cell morphology in an epithelium: constructing a quantitative dynamical model. |
| title_short | Cadherin-dependent cell morphology in an epithelium: constructing a quantitative dynamical model. |
| title_sort | cadherin dependent cell morphology in an epithelium constructing a quantitative dynamical model |
| url | http://europepmc.org/articles/PMC3140965?pdf=render |
| work_keys_str_mv | AT ianmgemp cadherindependentcellmorphologyinanepitheliumconstructingaquantitativedynamicalmodel AT richardwcarthew cadherindependentcellmorphologyinanepitheliumconstructingaquantitativedynamicalmodel AT saschahilgenfeldt cadherindependentcellmorphologyinanepitheliumconstructingaquantitativedynamicalmodel |