Updates and Challenges in ENS Cell Therapy for the Treatment of Neurointestinal Diseases
Neurointestinal diseases represent a significant challenge in clinical management with current palliative approaches failing to overcome disease and treatment-related morbidity. The recent progress with cell therapy to restore missing or defective components of the gut neuromusculature offers new ho...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/14/2/229 |
| _version_ | 1797298736562438144 |
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| author | Takahiro Ohkura Alan J. Burns Ryo Hotta |
| author_facet | Takahiro Ohkura Alan J. Burns Ryo Hotta |
| author_sort | Takahiro Ohkura |
| collection | DOAJ |
| description | Neurointestinal diseases represent a significant challenge in clinical management with current palliative approaches failing to overcome disease and treatment-related morbidity. The recent progress with cell therapy to restore missing or defective components of the gut neuromusculature offers new hope for potential cures. This review discusses the progress that has been made in the sourcing of putative stem cells and the studies into their biology and therapeutic potential. We also explore some of the practical challenges that must be overcome before cell-based therapies can be applied in the clinical setting. Although a number of obstacles remain, the rapid advances made in the enteric neural stem cell field suggest that such therapies are on the near horizon. |
| first_indexed | 2024-03-07T22:40:17Z |
| format | Article |
| id | doaj.art-0bda0ee17c174098b16f7b99df051f14 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-07T22:40:17Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-0bda0ee17c174098b16f7b99df051f142024-02-23T15:09:26ZengMDPI AGBiomolecules2218-273X2024-02-0114222910.3390/biom14020229Updates and Challenges in ENS Cell Therapy for the Treatment of Neurointestinal DiseasesTakahiro Ohkura0Alan J. Burns1Ryo Hotta2Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USADepartment of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USADepartment of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USANeurointestinal diseases represent a significant challenge in clinical management with current palliative approaches failing to overcome disease and treatment-related morbidity. The recent progress with cell therapy to restore missing or defective components of the gut neuromusculature offers new hope for potential cures. This review discusses the progress that has been made in the sourcing of putative stem cells and the studies into their biology and therapeutic potential. We also explore some of the practical challenges that must be overcome before cell-based therapies can be applied in the clinical setting. Although a number of obstacles remain, the rapid advances made in the enteric neural stem cell field suggest that such therapies are on the near horizon.https://www.mdpi.com/2218-273X/14/2/229cell therapyneurointestinal diseasescell transplantationenteric neural crest-derived cellsregenerative medicine |
| spellingShingle | Takahiro Ohkura Alan J. Burns Ryo Hotta Updates and Challenges in ENS Cell Therapy for the Treatment of Neurointestinal Diseases Biomolecules cell therapy neurointestinal diseases cell transplantation enteric neural crest-derived cells regenerative medicine |
| title | Updates and Challenges in ENS Cell Therapy for the Treatment of Neurointestinal Diseases |
| title_full | Updates and Challenges in ENS Cell Therapy for the Treatment of Neurointestinal Diseases |
| title_fullStr | Updates and Challenges in ENS Cell Therapy for the Treatment of Neurointestinal Diseases |
| title_full_unstemmed | Updates and Challenges in ENS Cell Therapy for the Treatment of Neurointestinal Diseases |
| title_short | Updates and Challenges in ENS Cell Therapy for the Treatment of Neurointestinal Diseases |
| title_sort | updates and challenges in ens cell therapy for the treatment of neurointestinal diseases |
| topic | cell therapy neurointestinal diseases cell transplantation enteric neural crest-derived cells regenerative medicine |
| url | https://www.mdpi.com/2218-273X/14/2/229 |
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