The Reproducibility and Usefulness of Estimated Average Glucose for Hyperglycemia Management during Health Checkups: A Retrospective Cross-Sectional Study
HbA1c reflects average glucose levels over 3 months, but it does not measure glycemic variability. This study aimed to determine the reproducibility and usefulness of HbA1c-derived estimated average glucose (eAG) and to analyze the factors associated with eAG during health checkups. This cross-secti...
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MDPI AG
2022-04-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/10/5/824 |
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| author | Eun-Hee Nah Seon Cho Hyeran Park Dongwon Noh Eunjoo Kwon Han-Ik Cho |
| author_facet | Eun-Hee Nah Seon Cho Hyeran Park Dongwon Noh Eunjoo Kwon Han-Ik Cho |
| author_sort | Eun-Hee Nah |
| collection | DOAJ |
| description | HbA1c reflects average glucose levels over 3 months, but it does not measure glycemic variability. This study aimed to determine the reproducibility and usefulness of HbA1c-derived estimated average glucose (eAG) and to analyze the factors associated with eAG during health checkups. This cross-sectional retrospective study consecutively selected subjects who had undergone health checkups at 16 health-promotion centers in 13 Korean cities in 2020. The subjects comprised 182,848 healthy subjects with normoglycemia, 109,555 with impaired fasting glucose (IFG), and 35,632 with diabetes. eAG was calculated using Nathan’s regression equation. In all subjects, fasting plasma glucose (FPG) was found to be fairly strongly correlated with eAG (r = 0.811). When the subjects were divided into FPG subgroups, the strength of the correlation decreased among those with normoglycemia and IFG (<i>p</i> < 0.001). Higher eAG levels were associated with older age, females, higher FPG, and lower HDL-C and triglycerides (<i>p</i> < 0.05). The proportion of subjects with a higher value of FPG than eAG was 46.3% in poorly controlled diabetic patients, compared with only 1.5% in normoglycemic subjects. This suggests eAG could help patients to understand their glycemic variability intuitively and healthcare providers to identify patients who might worsen in hyperglycemia control through measuring the difference between eAG and FPG. |
| first_indexed | 2024-03-10T03:47:57Z |
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| id | doaj.art-0bda617d71e44be39586b95319ce2e60 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-10T03:47:57Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
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| series | Healthcare |
| spelling | doaj.art-0bda617d71e44be39586b95319ce2e602023-11-23T11:13:36ZengMDPI AGHealthcare2227-90322022-04-0110582410.3390/healthcare10050824The Reproducibility and Usefulness of Estimated Average Glucose for Hyperglycemia Management during Health Checkups: A Retrospective Cross-Sectional StudyEun-Hee Nah0Seon Cho1Hyeran Park2Dongwon Noh3Eunjoo Kwon4Han-Ik Cho5Department of Laboratory Medicine and Health Promotion Research Institute, Korea Association of Health Promotion, Seoul 07572, KoreaDepartment of Laboratory Medicine and Health Promotion Research Institute, Korea Association of Health Promotion, Seoul 07572, KoreaDepartment of Laboratory Medicine and Health Promotion Research Institute, Korea Association of Health Promotion, Seoul 07572, KoreaDepartment of Laboratory Medicine and Health Promotion Research Institute, Korea Association of Health Promotion, Seoul 07572, KoreaDepartment of Laboratory Medicine and Health Promotion Research Institute, Korea Association of Health Promotion, Seoul 07572, KoreaMEDIcheck LAB, Korea Association of Health Promotion, Seoul 07572, KoreaHbA1c reflects average glucose levels over 3 months, but it does not measure glycemic variability. This study aimed to determine the reproducibility and usefulness of HbA1c-derived estimated average glucose (eAG) and to analyze the factors associated with eAG during health checkups. This cross-sectional retrospective study consecutively selected subjects who had undergone health checkups at 16 health-promotion centers in 13 Korean cities in 2020. The subjects comprised 182,848 healthy subjects with normoglycemia, 109,555 with impaired fasting glucose (IFG), and 35,632 with diabetes. eAG was calculated using Nathan’s regression equation. In all subjects, fasting plasma glucose (FPG) was found to be fairly strongly correlated with eAG (r = 0.811). When the subjects were divided into FPG subgroups, the strength of the correlation decreased among those with normoglycemia and IFG (<i>p</i> < 0.001). Higher eAG levels were associated with older age, females, higher FPG, and lower HDL-C and triglycerides (<i>p</i> < 0.05). The proportion of subjects with a higher value of FPG than eAG was 46.3% in poorly controlled diabetic patients, compared with only 1.5% in normoglycemic subjects. This suggests eAG could help patients to understand their glycemic variability intuitively and healthcare providers to identify patients who might worsen in hyperglycemia control through measuring the difference between eAG and FPG.https://www.mdpi.com/2227-9032/10/5/824estimated average glucosefasting plasma glucosehemoglobin A1cimpaired fasting glucosediabetes |
| spellingShingle | Eun-Hee Nah Seon Cho Hyeran Park Dongwon Noh Eunjoo Kwon Han-Ik Cho The Reproducibility and Usefulness of Estimated Average Glucose for Hyperglycemia Management during Health Checkups: A Retrospective Cross-Sectional Study Healthcare estimated average glucose fasting plasma glucose hemoglobin A1c impaired fasting glucose diabetes |
| title | The Reproducibility and Usefulness of Estimated Average Glucose for Hyperglycemia Management during Health Checkups: A Retrospective Cross-Sectional Study |
| title_full | The Reproducibility and Usefulness of Estimated Average Glucose for Hyperglycemia Management during Health Checkups: A Retrospective Cross-Sectional Study |
| title_fullStr | The Reproducibility and Usefulness of Estimated Average Glucose for Hyperglycemia Management during Health Checkups: A Retrospective Cross-Sectional Study |
| title_full_unstemmed | The Reproducibility and Usefulness of Estimated Average Glucose for Hyperglycemia Management during Health Checkups: A Retrospective Cross-Sectional Study |
| title_short | The Reproducibility and Usefulness of Estimated Average Glucose for Hyperglycemia Management during Health Checkups: A Retrospective Cross-Sectional Study |
| title_sort | reproducibility and usefulness of estimated average glucose for hyperglycemia management during health checkups a retrospective cross sectional study |
| topic | estimated average glucose fasting plasma glucose hemoglobin A1c impaired fasting glucose diabetes |
| url | https://www.mdpi.com/2227-9032/10/5/824 |
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