Hormone Replacement Therapy Does Not Eliminate Risk Factors for Joint Complications following Total Joint Arthroplasty: A Matched Cohort Study
Aging causes a reduction in testosterone and estrogen, which is linked to diminished bone mineral density. Hormone replacement therapy and its effect on the outcome of joint arthroplasties is unclear. The purpose of this study was to analyze the impact of testosterone replacement therapy (TRT) and e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Pathophysiology |
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| Online Access: | https://www.mdpi.com/1873-149X/30/2/11 |
| _version_ | 1797593091218079744 |
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| author | Lacee K. Collins Matthew W. Cole Timothy L. Waters Michael Iloanya Patrick A. Massey William F. Sherman |
| author_facet | Lacee K. Collins Matthew W. Cole Timothy L. Waters Michael Iloanya Patrick A. Massey William F. Sherman |
| author_sort | Lacee K. Collins |
| collection | DOAJ |
| description | Aging causes a reduction in testosterone and estrogen, which is linked to diminished bone mineral density. Hormone replacement therapy and its effect on the outcome of joint arthroplasties is unclear. The purpose of this study was to analyze the impact of testosterone replacement therapy (TRT) and estrogen replacement therapy (ERT) on the medical and joint outcomes of total hip (THA) and total knee arthroplasties (TKA). A retrospective cohort study was conducted using the PearlDiver database. Patients who received TRT or ERT perioperatively were matched to controls. Rates of 90-day medical complications and 2-year joint complications were queried. Patients who received TRT had an increased risk of revision, periprosthetic joint infection, and pooled joint complications within 2 years following a THA and increased rates of septic and aseptic revisions, and aseptic loosening after TKA compared to the control cohort. Patients receiving ERT had increased rates of aseptic loosening and pooled joint complications within 2 years following THA and increased rates of all-cause revisions and pooled joint complications after TKA. Patients who received TRT demonstrated significantly higher rates of revision rates and PJI. Patients who received perioperative ERT were significantly more likely to have increased risks of revision rates and joint infections. |
| first_indexed | 2024-03-11T02:03:51Z |
| format | Article |
| id | doaj.art-0bdba2a65fdd4045b139e194ec0ef059 |
| institution | Directory Open Access Journal |
| issn | 1873-149X |
| language | English |
| last_indexed | 2024-03-11T02:03:51Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathophysiology |
| spelling | doaj.art-0bdba2a65fdd4045b139e194ec0ef0592023-11-18T12:00:56ZengMDPI AGPathophysiology1873-149X2023-04-0130212313510.3390/pathophysiology30020011Hormone Replacement Therapy Does Not Eliminate Risk Factors for Joint Complications following Total Joint Arthroplasty: A Matched Cohort StudyLacee K. Collins0Matthew W. Cole1Timothy L. Waters2Michael Iloanya3Patrick A. Massey4William F. Sherman5Department of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Orthopaedic Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USADepartment of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USAAging causes a reduction in testosterone and estrogen, which is linked to diminished bone mineral density. Hormone replacement therapy and its effect on the outcome of joint arthroplasties is unclear. The purpose of this study was to analyze the impact of testosterone replacement therapy (TRT) and estrogen replacement therapy (ERT) on the medical and joint outcomes of total hip (THA) and total knee arthroplasties (TKA). A retrospective cohort study was conducted using the PearlDiver database. Patients who received TRT or ERT perioperatively were matched to controls. Rates of 90-day medical complications and 2-year joint complications were queried. Patients who received TRT had an increased risk of revision, periprosthetic joint infection, and pooled joint complications within 2 years following a THA and increased rates of septic and aseptic revisions, and aseptic loosening after TKA compared to the control cohort. Patients receiving ERT had increased rates of aseptic loosening and pooled joint complications within 2 years following THA and increased rates of all-cause revisions and pooled joint complications after TKA. Patients who received TRT demonstrated significantly higher rates of revision rates and PJI. Patients who received perioperative ERT were significantly more likely to have increased risks of revision rates and joint infections.https://www.mdpi.com/1873-149X/30/2/11arthroplastyhiphormone replacement therapycomplicationstestosteroneestrogen |
| spellingShingle | Lacee K. Collins Matthew W. Cole Timothy L. Waters Michael Iloanya Patrick A. Massey William F. Sherman Hormone Replacement Therapy Does Not Eliminate Risk Factors for Joint Complications following Total Joint Arthroplasty: A Matched Cohort Study Pathophysiology arthroplasty hip hormone replacement therapy complications testosterone estrogen |
| title | Hormone Replacement Therapy Does Not Eliminate Risk Factors for Joint Complications following Total Joint Arthroplasty: A Matched Cohort Study |
| title_full | Hormone Replacement Therapy Does Not Eliminate Risk Factors for Joint Complications following Total Joint Arthroplasty: A Matched Cohort Study |
| title_fullStr | Hormone Replacement Therapy Does Not Eliminate Risk Factors for Joint Complications following Total Joint Arthroplasty: A Matched Cohort Study |
| title_full_unstemmed | Hormone Replacement Therapy Does Not Eliminate Risk Factors for Joint Complications following Total Joint Arthroplasty: A Matched Cohort Study |
| title_short | Hormone Replacement Therapy Does Not Eliminate Risk Factors for Joint Complications following Total Joint Arthroplasty: A Matched Cohort Study |
| title_sort | hormone replacement therapy does not eliminate risk factors for joint complications following total joint arthroplasty a matched cohort study |
| topic | arthroplasty hip hormone replacement therapy complications testosterone estrogen |
| url | https://www.mdpi.com/1873-149X/30/2/11 |
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