Chronic Inhibition of Nitric Oxide Synthases Impairs Spatiotemporal Learning and Memory to a Similar Extent in C57BL/6 and hAPP23+/− Mice
Due to global population growth, age-related disorders like cardiovascular disease and dementia are anticipated to increase. Recent data suggests a connection between cardiovascular disease and neurodegeneration, especially focusing on arterial stiffness (AS) and Alzheimer’s disease (AD). In light o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | International Journal of Translational Medicine |
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| Online Access: | https://www.mdpi.com/2673-8937/3/4/36 |
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| author | Jhana O. Hendrickx Elke Calus Peter Paul De Deyn Debby Van Dam Guido R. Y. De Meyer |
| author_facet | Jhana O. Hendrickx Elke Calus Peter Paul De Deyn Debby Van Dam Guido R. Y. De Meyer |
| author_sort | Jhana O. Hendrickx |
| collection | DOAJ |
| description | Due to global population growth, age-related disorders like cardiovascular disease and dementia are anticipated to increase. Recent data suggests a connection between cardiovascular disease and neurodegeneration, especially focusing on arterial stiffness (AS) and Alzheimer’s disease (AD). In light of this, we conducted a study to explore the impact of long-term nitric oxide synthase (NOS) isoform inhibition, which leads to AS, on neurobehavioral performance. We also compared these effects in an AD model and control mice. C57BL/6 and hAPP23+/− mice (an established AD model) were given 0.5 mg/mL N(G)-Nitro-L-Arginine Methyl Ester (L-NAME) in their drinking water for 16 weeks. Our findings indicate that chronic non-selective NOS inhibition increased AS and reduced spatiotemporal learning and memory in both C57BL/6 and hAPP23+/− mice. These effects were consistent across both groups, emphasizing the role of neuronal NOS (nNOS) in cognitive aging, regardless of genetic predisposition to AD. |
| first_indexed | 2024-03-08T20:40:28Z |
| format | Article |
| id | doaj.art-0bdd1fa5e5564203bc17cc51c18f884c |
| institution | Directory Open Access Journal |
| issn | 2673-8937 |
| language | English |
| last_indexed | 2024-03-08T20:40:28Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Translational Medicine |
| spelling | doaj.art-0bdd1fa5e5564203bc17cc51c18f884c2023-12-22T14:15:37ZengMDPI AGInternational Journal of Translational Medicine2673-89372023-12-013451652610.3390/ijtm3040036Chronic Inhibition of Nitric Oxide Synthases Impairs Spatiotemporal Learning and Memory to a Similar Extent in C57BL/6 and hAPP23+/− MiceJhana O. Hendrickx0Elke Calus1Peter Paul De Deyn2Debby Van Dam3Guido R. Y. De Meyer4Laboratory of Physiopharmacology, University of Antwerp, Wilrijk, 2610 Antwerp, BelgiumLaboratory of Neurochemistry and Behaviour, Experimental Neurobiology Unit, Wilrijk, 2610 Antwerp, BelgiumLaboratory of Neurochemistry and Behaviour, Experimental Neurobiology Unit, Wilrijk, 2610 Antwerp, BelgiumLaboratory of Neurochemistry and Behaviour, Experimental Neurobiology Unit, Wilrijk, 2610 Antwerp, BelgiumLaboratory of Physiopharmacology, University of Antwerp, Wilrijk, 2610 Antwerp, BelgiumDue to global population growth, age-related disorders like cardiovascular disease and dementia are anticipated to increase. Recent data suggests a connection between cardiovascular disease and neurodegeneration, especially focusing on arterial stiffness (AS) and Alzheimer’s disease (AD). In light of this, we conducted a study to explore the impact of long-term nitric oxide synthase (NOS) isoform inhibition, which leads to AS, on neurobehavioral performance. We also compared these effects in an AD model and control mice. C57BL/6 and hAPP23+/− mice (an established AD model) were given 0.5 mg/mL N(G)-Nitro-L-Arginine Methyl Ester (L-NAME) in their drinking water for 16 weeks. Our findings indicate that chronic non-selective NOS inhibition increased AS and reduced spatiotemporal learning and memory in both C57BL/6 and hAPP23+/− mice. These effects were consistent across both groups, emphasizing the role of neuronal NOS (nNOS) in cognitive aging, regardless of genetic predisposition to AD.https://www.mdpi.com/2673-8937/3/4/36arterial stiffnessAlzheimer’s diseasenitric oxidelearning and memoryamyloid |
| spellingShingle | Jhana O. Hendrickx Elke Calus Peter Paul De Deyn Debby Van Dam Guido R. Y. De Meyer Chronic Inhibition of Nitric Oxide Synthases Impairs Spatiotemporal Learning and Memory to a Similar Extent in C57BL/6 and hAPP23+/− Mice International Journal of Translational Medicine arterial stiffness Alzheimer’s disease nitric oxide learning and memory amyloid |
| title | Chronic Inhibition of Nitric Oxide Synthases Impairs Spatiotemporal Learning and Memory to a Similar Extent in C57BL/6 and hAPP23+/− Mice |
| title_full | Chronic Inhibition of Nitric Oxide Synthases Impairs Spatiotemporal Learning and Memory to a Similar Extent in C57BL/6 and hAPP23+/− Mice |
| title_fullStr | Chronic Inhibition of Nitric Oxide Synthases Impairs Spatiotemporal Learning and Memory to a Similar Extent in C57BL/6 and hAPP23+/− Mice |
| title_full_unstemmed | Chronic Inhibition of Nitric Oxide Synthases Impairs Spatiotemporal Learning and Memory to a Similar Extent in C57BL/6 and hAPP23+/− Mice |
| title_short | Chronic Inhibition of Nitric Oxide Synthases Impairs Spatiotemporal Learning and Memory to a Similar Extent in C57BL/6 and hAPP23+/− Mice |
| title_sort | chronic inhibition of nitric oxide synthases impairs spatiotemporal learning and memory to a similar extent in c57bl 6 and happ23 mice |
| topic | arterial stiffness Alzheimer’s disease nitric oxide learning and memory amyloid |
| url | https://www.mdpi.com/2673-8937/3/4/36 |
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