The Immunomodulatory Properties of the Human Amnion-Derived Mesenchymal Stromal/Stem Cells Are Induced by INF-γ Produced by Activated Lymphomonocytes and Are Mediated by Cell-To-Cell Contact and Soluble Factors

The Immunomodulatory Properties of the Human Amnion-Derived Mesenchymal Stromal/Stem Cells Are Induced by INF-γ Produced by Activated Lymphomonocytes and Are Mediated by Cell-To-Cell Contact and Soluble Factors

Human mesenchymal stromal/stem cells (MSCs), being immunoprivileged and having immunomodulatory ability, represent a promising tool to be applied in the field of regenerative medicine. Based on numerous in vitro evidences, the immunological effects of MSCs on immune cells could depend on different m...

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Bibliographic Details
Main Authors: Matteo Bulati, Vitale Miceli, Alessia Gallo, Giandomenico Amico, Claudia Carcione, Mariangela Pampalone, Pier Giulio Conaldi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
human amnion-derived mesenchymal stem cells
immunomodulation
interferon-γ
primed-hAMSCs
regenerative medicine
exosomes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00054/full

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