Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease
<p>Abstract</p> <p>Background</p> <p>Alterations in blood–brain barrier permeability have been proposed to represent a relevant factor contributing to Parkinson’s disease progression. However, few studies have addressed this issue in patients at different stages of dise...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-08-01
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| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | http://www.jneuroinflammation.com/content/9/1/188 |
| _version_ | 1811248112659857408 |
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| author | Pisani Valerio Stefani Alessandro Pierantozzi Mariangela Natoli Silvia Stanzione Paolo Franciotta Diego Pisani Antonio |
| author_facet | Pisani Valerio Stefani Alessandro Pierantozzi Mariangela Natoli Silvia Stanzione Paolo Franciotta Diego Pisani Antonio |
| author_sort | Pisani Valerio |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Alterations in blood–brain barrier permeability have been proposed to represent a relevant factor contributing to Parkinson’s disease progression. However, few studies have addressed this issue in patients at different stages of disease.</p> <p>Methods</p> <p>Albumin was measured in cerebrospinal fluid and serum samples obtained from 73 non-demented subjects with idiopathic Parkinson’s disease and 47 age-matched control subjects. The albumin ratio (AR) was calculated to assess blood-cerebrospinal fluid and blood–brain barrier function. The group of patients with Parkinson’s disease included 46 subjects with Hoehn-Yahr staging between 1 and 2 and 27, with a score ranging from 2.5 to 4.</p> <p>Results</p> <p>Statistically significant differences in albumin ratio were found between patients with advanced disease, and both early-stage and unaffected groups. Conversely, early-phase patients did not differ from healthy subjects. Additionally, dopaminergic treatment seems to exert a possible effect on AR values<b>.</b></p> <p>Conclusions</p> <p>Our study demonstrates that possible dysfunction of the blood-cerebrospinal fluid barrier, blood–brain barrier, or both, characterize Parkinson’s disease progression. The associations between clinical scores, treatments and biochemical findings suggest a progressive impairment of barrier integrity during the course of the disease.</p> |
| first_indexed | 2024-04-12T15:21:18Z |
| format | Article |
| id | doaj.art-0bde0cfc1beb4bafa35fe3a24b8c67a3 |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-04-12T15:21:18Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-0bde0cfc1beb4bafa35fe3a24b8c67a32022-12-22T03:27:24ZengBMCJournal of Neuroinflammation1742-20942012-08-019118810.1186/1742-2094-9-188Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s diseasePisani ValerioStefani AlessandroPierantozzi MariangelaNatoli SilviaStanzione PaoloFranciotta DiegoPisani Antonio<p>Abstract</p> <p>Background</p> <p>Alterations in blood–brain barrier permeability have been proposed to represent a relevant factor contributing to Parkinson’s disease progression. However, few studies have addressed this issue in patients at different stages of disease.</p> <p>Methods</p> <p>Albumin was measured in cerebrospinal fluid and serum samples obtained from 73 non-demented subjects with idiopathic Parkinson’s disease and 47 age-matched control subjects. The albumin ratio (AR) was calculated to assess blood-cerebrospinal fluid and blood–brain barrier function. The group of patients with Parkinson’s disease included 46 subjects with Hoehn-Yahr staging between 1 and 2 and 27, with a score ranging from 2.5 to 4.</p> <p>Results</p> <p>Statistically significant differences in albumin ratio were found between patients with advanced disease, and both early-stage and unaffected groups. Conversely, early-phase patients did not differ from healthy subjects. Additionally, dopaminergic treatment seems to exert a possible effect on AR values<b>.</b></p> <p>Conclusions</p> <p>Our study demonstrates that possible dysfunction of the blood-cerebrospinal fluid barrier, blood–brain barrier, or both, characterize Parkinson’s disease progression. The associations between clinical scores, treatments and biochemical findings suggest a progressive impairment of barrier integrity during the course of the disease.</p>http://www.jneuroinflammation.com/content/9/1/188Albumin ratioBlood–brain barrierBlood-cerebrospinal fluid barrierCerebrospinal fluidParkinson’s disease |
| spellingShingle | Pisani Valerio Stefani Alessandro Pierantozzi Mariangela Natoli Silvia Stanzione Paolo Franciotta Diego Pisani Antonio Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease Journal of Neuroinflammation Albumin ratio Blood–brain barrier Blood-cerebrospinal fluid barrier Cerebrospinal fluid Parkinson’s disease |
| title | Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease |
| title_full | Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease |
| title_fullStr | Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease |
| title_full_unstemmed | Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease |
| title_short | Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease |
| title_sort | increased blood cerebrospinal fluid transfer of albumin in advanced parkinson s disease |
| topic | Albumin ratio Blood–brain barrier Blood-cerebrospinal fluid barrier Cerebrospinal fluid Parkinson’s disease |
| url | http://www.jneuroinflammation.com/content/9/1/188 |
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