Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents
<h4>Background</h4> It has been shown that vitamin D is associated with obesity and the development of atherosclerosis. Less is known about this association among adolescents with obesity. <h4>Objectives</h4> To determine the association of vitamin D level and metabolic risk...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519449/?tool=EBI |
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| author | Indah K. Murni Dian C. Sulistyoningrum Danijela Gasevic Rina Susilowati Madarina Julia |
| author_facet | Indah K. Murni Dian C. Sulistyoningrum Danijela Gasevic Rina Susilowati Madarina Julia |
| author_sort | Indah K. Murni |
| collection | DOAJ |
| description | <h4>Background</h4> It has been shown that vitamin D is associated with obesity and the development of atherosclerosis. Less is known about this association among adolescents with obesity. <h4>Objectives</h4> To determine the association of vitamin D level and metabolic risk factors with carotid intima-media thickness (CIMT) among obese adolescents. <h4>Methods</h4> We conducted a cross-sectional study among obese children aged 15 to 17 years in Yogyakarta, Indonesia. The association of vitamin D and other metabolic risk factors (triglyceride, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), and insulin resistance using homeostasis model assessment of insulin resistance (HOMA-IR)) with CIMT was explored by multivariable linear regression models. <h4>Results</h4> Out of 156 obese adolescents, 55.8% were boys. Compared to girls, boys had higher BMI z-score, waist circumference, and HDL-cholesterol. After adjustment for age, sex and second-hand smoke exposure, high HOMA-IR, total cholesterol, LDL-cholesterol and triglyceride levels were associated with higher odds of elevated CIMT. In analyses stratified by sex, a similar trend was observed in boys, while none of the risk factors were associated with CIMT in girls. We observed no association between vitamin D and CIMT. <h4>Conclusions</h4> Hyperinsulinemia, higher total cholesterol and LDL cholesterol were associated with greater odds of elevated CIMT among obese adolescent boys. |
| first_indexed | 2024-12-21T07:42:26Z |
| format | Article |
| id | doaj.art-0bde46c9febd4cf19d42e649f56bc7a9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T07:42:26Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0bde46c9febd4cf19d42e649f56bc7a92022-12-21T19:11:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011610Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescentsIndah K. MurniDian C. SulistyoningrumDanijela GasevicRina SusilowatiMadarina Julia<h4>Background</h4> It has been shown that vitamin D is associated with obesity and the development of atherosclerosis. Less is known about this association among adolescents with obesity. <h4>Objectives</h4> To determine the association of vitamin D level and metabolic risk factors with carotid intima-media thickness (CIMT) among obese adolescents. <h4>Methods</h4> We conducted a cross-sectional study among obese children aged 15 to 17 years in Yogyakarta, Indonesia. The association of vitamin D and other metabolic risk factors (triglyceride, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), and insulin resistance using homeostasis model assessment of insulin resistance (HOMA-IR)) with CIMT was explored by multivariable linear regression models. <h4>Results</h4> Out of 156 obese adolescents, 55.8% were boys. Compared to girls, boys had higher BMI z-score, waist circumference, and HDL-cholesterol. After adjustment for age, sex and second-hand smoke exposure, high HOMA-IR, total cholesterol, LDL-cholesterol and triglyceride levels were associated with higher odds of elevated CIMT. In analyses stratified by sex, a similar trend was observed in boys, while none of the risk factors were associated with CIMT in girls. We observed no association between vitamin D and CIMT. <h4>Conclusions</h4> Hyperinsulinemia, higher total cholesterol and LDL cholesterol were associated with greater odds of elevated CIMT among obese adolescent boys.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519449/?tool=EBI |
| spellingShingle | Indah K. Murni Dian C. Sulistyoningrum Danijela Gasevic Rina Susilowati Madarina Julia Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents PLoS ONE |
| title | Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents |
| title_full | Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents |
| title_fullStr | Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents |
| title_full_unstemmed | Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents |
| title_short | Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents |
| title_sort | sex differences in the association of vitamin d and metabolic risk factors with carotid intima media thickness in obese adolescents |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519449/?tool=EBI |
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