MiR-139-3p is related to left ventricular hypertrophy and cardiomyocyte apoptosis in two-kidney one-clip hypertensive rats
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression in many physiological and pathological processes. Previous studies have reported the role of miR-139-3p in cancer. However, its specific roles and functions in the heart undergoing hypertrophy have yet to be...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Belgrade, University of Novi Sad
2015-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2015/0354-46641500008Y.pdf |
| Summary: | MicroRNAs (miRNAs) are important post-transcriptional regulators of gene
expression in many physiological and pathological processes. Previous studies
have reported the role of miR-139-3p in cancer. However, its specific roles
and functions in the heart undergoing hypertrophy have yet to be fully
elucidated. In the present study, a significant upregulation of miR-139-3p
expression was demonstrated in the left ventricular myocardium of two-kidney
one-clip (2K1C) hypertensive rats using microarray and quantitative real-time
PCR (qRT-PCR). Based on computational analysis, we observed that miR-139-3p
can control the expression of mitogen-activated protein kinase 1 (MAPK1) as a
target gene, which is essential for the induction of cardiac hypertrophy and
cardiomyocyte apoptosis. This study provides first information that the
highly expressed miR-139-3p might be closely involved in MAPK1-mediated
cardiac hypertrophy and cardiomyocyte apoptotic processes in 2K1C rat. |
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| ISSN: | 0354-4664 1821-4339 |