MiR-139-3p is related to left ventricular hypertrophy and cardiomyocyte apoptosis in two-kidney one-clip hypertensive rats
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression in many physiological and pathological processes. Previous studies have reported the role of miR-139-3p in cancer. However, its specific roles and functions in the heart undergoing hypertrophy have yet to be...
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| Format: | Article |
| Language: | English |
| Published: |
University of Belgrade, University of Novi Sad
2015-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2015/0354-46641500008Y.pdf |
| _version_ | 1828292683373740032 |
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| author | Yang Xiaomin Yu Hui Hu Hai Yue Jianwei Tian Xuyang Wang Cong Yan Xulong Sun Gang Wang Zhanli |
| author_facet | Yang Xiaomin Yu Hui Hu Hai Yue Jianwei Tian Xuyang Wang Cong Yan Xulong Sun Gang Wang Zhanli |
| author_sort | Yang Xiaomin |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are important post-transcriptional regulators of gene
expression in many physiological and pathological processes. Previous studies
have reported the role of miR-139-3p in cancer. However, its specific roles
and functions in the heart undergoing hypertrophy have yet to be fully
elucidated. In the present study, a significant upregulation of miR-139-3p
expression was demonstrated in the left ventricular myocardium of two-kidney
one-clip (2K1C) hypertensive rats using microarray and quantitative real-time
PCR (qRT-PCR). Based on computational analysis, we observed that miR-139-3p
can control the expression of mitogen-activated protein kinase 1 (MAPK1) as a
target gene, which is essential for the induction of cardiac hypertrophy and
cardiomyocyte apoptosis. This study provides first information that the
highly expressed miR-139-3p might be closely involved in MAPK1-mediated
cardiac hypertrophy and cardiomyocyte apoptotic processes in 2K1C rat. |
| first_indexed | 2024-04-13T11:11:47Z |
| format | Article |
| id | doaj.art-0bde95139afb49d1a9f50ebcd4853a6b |
| institution | Directory Open Access Journal |
| issn | 0354-4664 1821-4339 |
| language | English |
| last_indexed | 2024-04-13T11:11:47Z |
| publishDate | 2015-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-0bde95139afb49d1a9f50ebcd4853a6b2022-12-22T02:49:05ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392015-01-0167242743510.2298/ABS140820008Y0354-46641500008YMiR-139-3p is related to left ventricular hypertrophy and cardiomyocyte apoptosis in two-kidney one-clip hypertensive ratsYang Xiaomin0Yu Hui1Hu Hai2Yue Jianwei3Tian Xuyang4Wang Cong5Yan Xulong6Sun Gang7Wang Zhanli8Baotou Medical College, The Second Affiliated Hospital, Department of Cardiovascular Medicine, Research Institute of Hypertension, Inner Mongolia Autonomous Region, Baotou, P.R. ChinaBaotou Medical College, Clinical Laboratory, Second Affiliated Hospital, Inner Mongolia Autonomous Region, Baotou, P.R. ChinaBaotou Medical College, Department of Pathophysiology, Inner Mongolia Autonomous Region, Baotou, P.R. ChinaBaotou Medical College, The Second Affiliated Hospital, Department of Cardiovascular Medicine, Research Institute of Hypertension, Inner Mongolia Autonomous Region, Baotou, P.R. ChinaBaotou Medical College, The Second Affiliated Hospital, Department of Cardiovascular Medicine, Research Institute of Hypertension, Inner Mongolia Autonomous Region, Baotou, P.R. ChinaBaotou Medical College, The Second Affiliated Hospital, Department of Cardiovascular Medicine, Research Institute of Hypertension, Inner Mongolia Autonomous Region, Baotou, P.R. ChinaBaotou Medical College, The Second Affiliated Hospital, Department of Cardiovascular Medicine, Research Institute of Hypertension, Inner Mongolia Autonomous Region, Baotou, P.R. ChinaBaotou Medical College, The Second Affiliated Hospital, Department of Cardiovascular Medicine, Research Institute of Hypertension, Inner Mongolia Autonomous Region, Baotou, P.R. ChinaBaotou Medical College, First Affiliated Hospital, Department of Laboratory Centre, Clinical Laboratory, Inner Mongolia Autonomous Region, Baotou, P.R. ChinaMicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression in many physiological and pathological processes. Previous studies have reported the role of miR-139-3p in cancer. However, its specific roles and functions in the heart undergoing hypertrophy have yet to be fully elucidated. In the present study, a significant upregulation of miR-139-3p expression was demonstrated in the left ventricular myocardium of two-kidney one-clip (2K1C) hypertensive rats using microarray and quantitative real-time PCR (qRT-PCR). Based on computational analysis, we observed that miR-139-3p can control the expression of mitogen-activated protein kinase 1 (MAPK1) as a target gene, which is essential for the induction of cardiac hypertrophy and cardiomyocyte apoptosis. This study provides first information that the highly expressed miR-139-3p might be closely involved in MAPK1-mediated cardiac hypertrophy and cardiomyocyte apoptotic processes in 2K1C rat.http://www.doiserbia.nb.rs/img/doi/0354-4664/2015/0354-46641500008Y.pdfhypertensiveMiR-139-3pcardiac hypertrophycardiomyocyte apoptosis |
| spellingShingle | Yang Xiaomin Yu Hui Hu Hai Yue Jianwei Tian Xuyang Wang Cong Yan Xulong Sun Gang Wang Zhanli MiR-139-3p is related to left ventricular hypertrophy and cardiomyocyte apoptosis in two-kidney one-clip hypertensive rats Archives of Biological Sciences hypertensive MiR-139-3p cardiac hypertrophy cardiomyocyte apoptosis |
| title | MiR-139-3p is related to left ventricular hypertrophy and cardiomyocyte apoptosis in two-kidney one-clip hypertensive rats |
| title_full | MiR-139-3p is related to left ventricular hypertrophy and cardiomyocyte apoptosis in two-kidney one-clip hypertensive rats |
| title_fullStr | MiR-139-3p is related to left ventricular hypertrophy and cardiomyocyte apoptosis in two-kidney one-clip hypertensive rats |
| title_full_unstemmed | MiR-139-3p is related to left ventricular hypertrophy and cardiomyocyte apoptosis in two-kidney one-clip hypertensive rats |
| title_short | MiR-139-3p is related to left ventricular hypertrophy and cardiomyocyte apoptosis in two-kidney one-clip hypertensive rats |
| title_sort | mir 139 3p is related to left ventricular hypertrophy and cardiomyocyte apoptosis in two kidney one clip hypertensive rats |
| topic | hypertensive MiR-139-3p cardiac hypertrophy cardiomyocyte apoptosis |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2015/0354-46641500008Y.pdf |
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