An atlas of Wnt activity during embryogenesis in Xenopus tropicalis.
Wnt proteins form a family of highly conserved secreted molecules that are critical mediators of cell-cell signaling during embryogenesis. Partial data on Wnt activity in different tissues and at different stages have been reported in frog embryos. Our objective here is to provide a coherent and det...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5908154?pdf=render |
| _version_ | 1819262833263640576 |
|---|---|
| author | Caroline Borday Karine Parain Hong Thi Tran Kris Vleminckx Muriel Perron Anne H Monsoro-Burq |
| author_facet | Caroline Borday Karine Parain Hong Thi Tran Kris Vleminckx Muriel Perron Anne H Monsoro-Burq |
| author_sort | Caroline Borday |
| collection | DOAJ |
| description | Wnt proteins form a family of highly conserved secreted molecules that are critical mediators of cell-cell signaling during embryogenesis. Partial data on Wnt activity in different tissues and at different stages have been reported in frog embryos. Our objective here is to provide a coherent and detailed description of Wnt activity throughout embryo development. Using a transgenic Xenopus tropicalis line carrying a Wnt-responsive reporter sequence, we depict the spatial and temporal dynamics of canonical Wnt activity during embryogenesis. We provide a comprehensive series of in situ hybridization in whole-mount embryos and in cross-sections, from gastrula to tadpole stages, with special focus on neural tube, retina and neural crest cell development. This collection of patterns will thus constitute a valuable resource for developmental biologists to picture the dynamics of Wnt activity during development. |
| first_indexed | 2024-12-23T20:03:58Z |
| format | Article |
| id | doaj.art-0bdf522920914900a251b4ac1a00b8b9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T20:03:58Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0bdf522920914900a251b4ac1a00b8b92022-12-21T17:33:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01134e019360610.1371/journal.pone.0193606An atlas of Wnt activity during embryogenesis in Xenopus tropicalis.Caroline BordayKarine ParainHong Thi TranKris VleminckxMuriel PerronAnne H Monsoro-BurqWnt proteins form a family of highly conserved secreted molecules that are critical mediators of cell-cell signaling during embryogenesis. Partial data on Wnt activity in different tissues and at different stages have been reported in frog embryos. Our objective here is to provide a coherent and detailed description of Wnt activity throughout embryo development. Using a transgenic Xenopus tropicalis line carrying a Wnt-responsive reporter sequence, we depict the spatial and temporal dynamics of canonical Wnt activity during embryogenesis. We provide a comprehensive series of in situ hybridization in whole-mount embryos and in cross-sections, from gastrula to tadpole stages, with special focus on neural tube, retina and neural crest cell development. This collection of patterns will thus constitute a valuable resource for developmental biologists to picture the dynamics of Wnt activity during development.http://europepmc.org/articles/PMC5908154?pdf=render |
| spellingShingle | Caroline Borday Karine Parain Hong Thi Tran Kris Vleminckx Muriel Perron Anne H Monsoro-Burq An atlas of Wnt activity during embryogenesis in Xenopus tropicalis. PLoS ONE |
| title | An atlas of Wnt activity during embryogenesis in Xenopus tropicalis. |
| title_full | An atlas of Wnt activity during embryogenesis in Xenopus tropicalis. |
| title_fullStr | An atlas of Wnt activity during embryogenesis in Xenopus tropicalis. |
| title_full_unstemmed | An atlas of Wnt activity during embryogenesis in Xenopus tropicalis. |
| title_short | An atlas of Wnt activity during embryogenesis in Xenopus tropicalis. |
| title_sort | atlas of wnt activity during embryogenesis in xenopus tropicalis |
| url | http://europepmc.org/articles/PMC5908154?pdf=render |
| work_keys_str_mv | AT carolineborday anatlasofwntactivityduringembryogenesisinxenopustropicalis AT karineparain anatlasofwntactivityduringembryogenesisinxenopustropicalis AT hongthitran anatlasofwntactivityduringembryogenesisinxenopustropicalis AT krisvleminckx anatlasofwntactivityduringembryogenesisinxenopustropicalis AT murielperron anatlasofwntactivityduringembryogenesisinxenopustropicalis AT annehmonsoroburq anatlasofwntactivityduringembryogenesisinxenopustropicalis AT carolineborday atlasofwntactivityduringembryogenesisinxenopustropicalis AT karineparain atlasofwntactivityduringembryogenesisinxenopustropicalis AT hongthitran atlasofwntactivityduringembryogenesisinxenopustropicalis AT krisvleminckx atlasofwntactivityduringembryogenesisinxenopustropicalis AT murielperron atlasofwntactivityduringembryogenesisinxenopustropicalis AT annehmonsoroburq atlasofwntactivityduringembryogenesisinxenopustropicalis |