Preparation and characterization of sol-gel processed spray dried silica xerogel microparticles as carriers of heparin sodium
A spray drying technique was used for xerogel microparticles preparation from acetic acid catalyzed tetraethoxysilane (TEOS) – based silica sol, TEOS co-hydrolyzed with methyltriethoxysilane (METES), or α,ω-silaneterminated poly(ethylene glycol). The effect of TEOS modification on the heparin dissol...
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| Format: | Article |
| Language: | English |
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Society of Chemists and Technologists of Macedonia
2006-12-01
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| Series: | Macedonian Journal of Chemistry and Chemical Engineering |
| Subjects: | |
| Online Access: | https://mjcce.org.mk/index.php/MJCCE/article/view/295 |
| _version_ | 1828888915192315904 |
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| author | Packa Antovska Maja Cvetkovska Katerina Goračinova |
| author_facet | Packa Antovska Maja Cvetkovska Katerina Goračinova |
| author_sort | Packa Antovska |
| collection | DOAJ |
| description | A spray drying technique was used for xerogel microparticles preparation from acetic acid catalyzed tetraethoxysilane (TEOS) – based silica sol, TEOS co-hydrolyzed with methyltriethoxysilane (METES), or α,ω-silaneterminated poly(ethylene glycol). The effect of TEOS modification on the heparin dissolution rate, particle degradation rate, as well as particle size and morphology was investigated. Smooth, spherical microparticles in the range of 1.02 – 13.51 μm, were produced by the spray drying method, which showed slow degradation rate and controlled release of heparin over prolonged period of time, dependent on the polymer’s composition. |
| first_indexed | 2024-12-13T12:31:09Z |
| format | Article |
| id | doaj.art-0be072007a4543f7b76a3c9e5a5ddb07 |
| institution | Directory Open Access Journal |
| issn | 1857-5552 1857-5625 |
| language | English |
| last_indexed | 2024-12-13T12:31:09Z |
| publishDate | 2006-12-01 |
| publisher | Society of Chemists and Technologists of Macedonia |
| record_format | Article |
| series | Macedonian Journal of Chemistry and Chemical Engineering |
| spelling | doaj.art-0be072007a4543f7b76a3c9e5a5ddb072022-12-21T23:46:01ZengSociety of Chemists and Technologists of MacedoniaMacedonian Journal of Chemistry and Chemical Engineering1857-55521857-56252006-12-01252121126167Preparation and characterization of sol-gel processed spray dried silica xerogel microparticles as carriers of heparin sodiumPacka Antovska0Maja Cvetkovska1Katerina Goračinova2Institute of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Ss. Cyril and Methodius University, Vodnjanska 17, 1000 Skopje,Faculty of Technology and Metallurgy, Ss. Cyril & Methodius University, Skopje,Institute of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Ss. Cyril and Methodius University, Vodnjanska 17, 1000 Skopje,A spray drying technique was used for xerogel microparticles preparation from acetic acid catalyzed tetraethoxysilane (TEOS) – based silica sol, TEOS co-hydrolyzed with methyltriethoxysilane (METES), or α,ω-silaneterminated poly(ethylene glycol). The effect of TEOS modification on the heparin dissolution rate, particle degradation rate, as well as particle size and morphology was investigated. Smooth, spherical microparticles in the range of 1.02 – 13.51 μm, were produced by the spray drying method, which showed slow degradation rate and controlled release of heparin over prolonged period of time, dependent on the polymer’s composition.https://mjcce.org.mk/index.php/MJCCE/article/view/295silica xerogelmicroparticlesspray dryingcontrolled releaseheparin |
| spellingShingle | Packa Antovska Maja Cvetkovska Katerina Goračinova Preparation and characterization of sol-gel processed spray dried silica xerogel microparticles as carriers of heparin sodium Macedonian Journal of Chemistry and Chemical Engineering silica xerogel microparticles spray drying controlled release heparin |
| title | Preparation and characterization of sol-gel processed spray dried silica xerogel microparticles as carriers of heparin sodium |
| title_full | Preparation and characterization of sol-gel processed spray dried silica xerogel microparticles as carriers of heparin sodium |
| title_fullStr | Preparation and characterization of sol-gel processed spray dried silica xerogel microparticles as carriers of heparin sodium |
| title_full_unstemmed | Preparation and characterization of sol-gel processed spray dried silica xerogel microparticles as carriers of heparin sodium |
| title_short | Preparation and characterization of sol-gel processed spray dried silica xerogel microparticles as carriers of heparin sodium |
| title_sort | preparation and characterization of sol gel processed spray dried silica xerogel microparticles as carriers of heparin sodium |
| topic | silica xerogel microparticles spray drying controlled release heparin |
| url | https://mjcce.org.mk/index.php/MJCCE/article/view/295 |
| work_keys_str_mv | AT packaantovska preparationandcharacterizationofsolgelprocessedspraydriedsilicaxerogelmicroparticlesascarriersofheparinsodium AT majacvetkovska preparationandcharacterizationofsolgelprocessedspraydriedsilicaxerogelmicroparticlesascarriersofheparinsodium AT katerinagoracinova preparationandcharacterizationofsolgelprocessedspraydriedsilicaxerogelmicroparticlesascarriersofheparinsodium |