Phenylethanoid and Phenylmethanoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their Bioactivities
The phytochemical study on the leaves of <i>Ligustrum robustum</i>, which have been used as Ku-Ding-Cha, led to the isolation and identification of three new phenylethanoid glycosides and three new phenylmethanoid glycosides, named ligurobustosides R<sub>1</sub> (<b>1b&...
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MDPI AG
2022-10-01
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| Online Access: | https://www.mdpi.com/1420-3049/27/21/7390 |
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| author | Shi-Hui Lu Hao-Jiang Zuo Jing Huang Ran Chen Jia-Ping Pan Xiu-Xia Li |
| author_facet | Shi-Hui Lu Hao-Jiang Zuo Jing Huang Ran Chen Jia-Ping Pan Xiu-Xia Li |
| author_sort | Shi-Hui Lu |
| collection | DOAJ |
| description | The phytochemical study on the leaves of <i>Ligustrum robustum</i>, which have been used as Ku-Ding-Cha, led to the isolation and identification of three new phenylethanoid glycosides and three new phenylmethanoid glycosides, named ligurobustosides R<sub>1</sub> (<b>1b</b>), R<sub>2–3</sub> (<b>2</b>), R<sub>4</sub> (<b>3</b>), S<sub>1</sub> (<b>4b</b>), S<sub>2</sub> (<b>5</b>), and S<sub>3</sub> (<b>6</b>), and five reported phenylethanoid glycosides (<b>7</b>–<b>11</b>). In the bioactivity test, (<i>Z</i>)-osmanthuside B<sub>6</sub> (<b>11</b>) displayed strong fatty acid synthase (FAS) inhibitory activity (IC<sub>50</sub>: 4.55 ± 0.35 μM) as the positive control orlistat (IC<sub>50</sub>: 4.46 ± 0.13 μM), while ligurobustosides R<sub>4</sub> (<b>3</b>) and S<sub>2</sub> (<b>5</b>), ligupurpuroside B (<b>7</b>), <i>cis</i>-ligupurpuroside B (<b>8</b>), ligurobustoside N (<b>9</b>), osmanthuside D (<b>10</b>), and (<i>Z</i>)-osmanthuside B<sub>6</sub> (<b>11</b>) showed stronger ABTS radical scavenging activity (IC<sub>50</sub>: 2.68 ± 0.05~4.86 ± 0.06 μM) than the positive control L-(+)-ascorbic acid (IC<sub>50</sub>: 10.06 ± 0.19 μM). This research provided a theoretical basis for the leaves of <i>L. robustum</i> as a tea with function in treating obesity and diabetes. |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:47:37Z |
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| spelling | doaj.art-0be0ca0450c34b21b98742b8ab64ec382023-11-24T06:03:25ZengMDPI AGMolecules1420-30492022-10-012721739010.3390/molecules27217390Phenylethanoid and Phenylmethanoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their BioactivitiesShi-Hui Lu0Hao-Jiang Zuo1Jing Huang2Ran Chen3Jia-Ping Pan4Xiu-Xia Li5College of Pharmacy, Youjiang Medical University for Nationalities, Baise 533000, ChinaDepartment of Laboratory Science of Public Health, West China School of Public Health, Sichuan University, Chengdu 610041, ChinaKey Laboratory of Drug Targeting, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, ChinaInstitute of Life Science, Youjiang Medical University for Nationalities, Baise 533000, ChinaCollege of Pharmacy, Youjiang Medical University for Nationalities, Baise 533000, ChinaNursing School, Youjiang Medical University for Nationalities, Baise 533000, ChinaThe phytochemical study on the leaves of <i>Ligustrum robustum</i>, which have been used as Ku-Ding-Cha, led to the isolation and identification of three new phenylethanoid glycosides and three new phenylmethanoid glycosides, named ligurobustosides R<sub>1</sub> (<b>1b</b>), R<sub>2–3</sub> (<b>2</b>), R<sub>4</sub> (<b>3</b>), S<sub>1</sub> (<b>4b</b>), S<sub>2</sub> (<b>5</b>), and S<sub>3</sub> (<b>6</b>), and five reported phenylethanoid glycosides (<b>7</b>–<b>11</b>). In the bioactivity test, (<i>Z</i>)-osmanthuside B<sub>6</sub> (<b>11</b>) displayed strong fatty acid synthase (FAS) inhibitory activity (IC<sub>50</sub>: 4.55 ± 0.35 μM) as the positive control orlistat (IC<sub>50</sub>: 4.46 ± 0.13 μM), while ligurobustosides R<sub>4</sub> (<b>3</b>) and S<sub>2</sub> (<b>5</b>), ligupurpuroside B (<b>7</b>), <i>cis</i>-ligupurpuroside B (<b>8</b>), ligurobustoside N (<b>9</b>), osmanthuside D (<b>10</b>), and (<i>Z</i>)-osmanthuside B<sub>6</sub> (<b>11</b>) showed stronger ABTS radical scavenging activity (IC<sub>50</sub>: 2.68 ± 0.05~4.86 ± 0.06 μM) than the positive control L-(+)-ascorbic acid (IC<sub>50</sub>: 10.06 ± 0.19 μM). This research provided a theoretical basis for the leaves of <i>L. robustum</i> as a tea with function in treating obesity and diabetes.https://www.mdpi.com/1420-3049/27/21/7390<i>Ligustrum robustum</i>phenylethanoid glycosidephenylmethanoid glycosidesFAS<i>α</i>-glucosidaseantioxidant |
| spellingShingle | Shi-Hui Lu Hao-Jiang Zuo Jing Huang Ran Chen Jia-Ping Pan Xiu-Xia Li Phenylethanoid and Phenylmethanoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their Bioactivities Molecules <i>Ligustrum robustum</i> phenylethanoid glycoside phenylmethanoid glycosides FAS <i>α</i>-glucosidase antioxidant |
| title | Phenylethanoid and Phenylmethanoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their Bioactivities |
| title_full | Phenylethanoid and Phenylmethanoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their Bioactivities |
| title_fullStr | Phenylethanoid and Phenylmethanoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their Bioactivities |
| title_full_unstemmed | Phenylethanoid and Phenylmethanoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their Bioactivities |
| title_short | Phenylethanoid and Phenylmethanoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their Bioactivities |
| title_sort | phenylethanoid and phenylmethanoid glycosides from the leaves of i ligustrum robustum i and their bioactivities |
| topic | <i>Ligustrum robustum</i> phenylethanoid glycoside phenylmethanoid glycosides FAS <i>α</i>-glucosidase antioxidant |
| url | https://www.mdpi.com/1420-3049/27/21/7390 |
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