Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime Derivatives
In this study, in order to find novel biologically active pyrazole oxime derivatives, twenty-eight new pyrazole oxime compounds containing a substituted isoxazole ring were synthesized and evaluated for their acaricidaland insecticidal activities. Bioassays exhibited that some target compounds indic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/22/12/2000 |
| _version_ | 1818255990644015104 |
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| author | Hong Dai Wei Yao Yuan Fang Siyu Sun Yujun Shi Jia Chen Guoqing Jiang Jian Shi |
| author_facet | Hong Dai Wei Yao Yuan Fang Siyu Sun Yujun Shi Jia Chen Guoqing Jiang Jian Shi |
| author_sort | Hong Dai |
| collection | DOAJ |
| description | In this study, in order to find novel biologically active pyrazole oxime derivatives, twenty-eight new pyrazole oxime compounds containing a substituted isoxazole ring were synthesized and evaluated for their acaricidaland insecticidal activities. Bioassays exhibited that some target compounds indicated good acaricidal and insecticidal activities against Tetranychus cinnabarinus, Aphis medicaginis, Mythimna separata, and Nilaparvata lugens. Especially, compounds 9c, 9h, 9u, and 9v showed 100.00%, 90.56%, 90.78%, and 90.62% insecticidal activities against A. medicaginis at the concentration of 20 μg/mL, respectively, compounds 9k and 9u had 70.86% and 100.00% insecticidal activities against M. separata at 20 μg/mL, respectively. |
| first_indexed | 2024-12-12T17:20:38Z |
| format | Article |
| id | doaj.art-0be278f7f6bc4f9b91c36fc208f1fccc |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-12T17:20:38Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-0be278f7f6bc4f9b91c36fc208f1fccc2022-12-22T00:17:40ZengMDPI AGMolecules1420-30492017-11-012212200010.3390/molecules22122000molecules22122000Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime DerivativesHong Dai0Wei Yao1Yuan Fang2Siyu Sun3Yujun Shi4Jia Chen5Guoqing Jiang6Jian Shi7College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, ChinaCollege of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, ChinaSchool of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, ChinaCollege of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, ChinaCollege of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, ChinaCollege of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, ChinaCollege of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, ChinaAnalysis and Testing Center, Nantong University, Nantong 226019, ChinaIn this study, in order to find novel biologically active pyrazole oxime derivatives, twenty-eight new pyrazole oxime compounds containing a substituted isoxazole ring were synthesized and evaluated for their acaricidaland insecticidal activities. Bioassays exhibited that some target compounds indicated good acaricidal and insecticidal activities against Tetranychus cinnabarinus, Aphis medicaginis, Mythimna separata, and Nilaparvata lugens. Especially, compounds 9c, 9h, 9u, and 9v showed 100.00%, 90.56%, 90.78%, and 90.62% insecticidal activities against A. medicaginis at the concentration of 20 μg/mL, respectively, compounds 9k and 9u had 70.86% and 100.00% insecticidal activities against M. separata at 20 μg/mL, respectively.https://www.mdpi.com/1420-3049/22/12/2000isoxazolepyrazole oximesynthesisbioactivity |
| spellingShingle | Hong Dai Wei Yao Yuan Fang Siyu Sun Yujun Shi Jia Chen Guoqing Jiang Jian Shi Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime Derivatives Molecules isoxazole pyrazole oxime synthesis bioactivity |
| title | Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime Derivatives |
| title_full | Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime Derivatives |
| title_fullStr | Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime Derivatives |
| title_full_unstemmed | Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime Derivatives |
| title_short | Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime Derivatives |
| title_sort | design synthesis and bioactivities of novel isoxazole containing pyrazole oxime derivatives |
| topic | isoxazole pyrazole oxime synthesis bioactivity |
| url | https://www.mdpi.com/1420-3049/22/12/2000 |
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