Inability of NS1 protein from an H5N1 influenza virus to activate PI3K/Akt signaling pathway correlates to the enhanced virus replication upon PI3K inhibition

Inability of NS1 protein from an H5N1 influenza virus to activate PI3K/Akt signaling pathway correlates to the enhanced virus replication upon PI3K inhibition

<p>Abstract</p> <p>Background</p> <p>Phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, activated during influenza A virus infection, can promote viral replication via multiple mechanisms. Direct binding of NS1 protein to p85β subunit of PI3K is required for ac...

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Bibliographic Details
Main Authors: Li Weizhong, Wang Gefei, Zhang Heng, Shen Yanqin, Dai Jianping, Wu Liqi, Zhou Jianxiang, Jiang Zhiwu, Li Kangsheng
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Veterinary Research
Online Access:http://www.veterinaryresearch.org

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