The tortuous diagnosis of one case of neonatal hyperthyroidism
Abstract Objective To outline the clinical signs, diagnosis, and course of care for a single case of neonatal hyperthyroidism while also summarizing common diagnostic errors related to this condition. Methods Medical records of the neonate of hyperthyroidism were collected and analyzed in combinatio...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-024-04531-6 |
| _version_ | 1797355484353658880 |
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| author | Lin Zhu Jing Wang Wei Liu |
| author_facet | Lin Zhu Jing Wang Wei Liu |
| author_sort | Lin Zhu |
| collection | DOAJ |
| description | Abstract Objective To outline the clinical signs, diagnosis, and course of care for a single case of neonatal hyperthyroidism while also summarizing common diagnostic errors related to this condition. Methods Medical records of the neonate of hyperthyroidism were collected and analyzed in combination with literature. Results The neonate’s mother had thyroid disease, but her thyrotropin receptor antibody (TRAb) levels were not monitored during pregnancy. The neonate exhibited typical symptoms of hyperthyroidism on the day of birth but was not diagnosed until 15 days later. Impaired liver (cholestasis, elevated liver enzymes) and cardiac function (pulmonary hypertension, right heart enlargement) are the main manifestations. Treatment with methimazole (1.0 mg /kg·d) and propranolol (2.0 mg /kg·d) led to recovery, and the neonate stayed in the hospital for 27 days before being discharged with medication. The diagnosis was temporary hyperthyroidism, and the medication was discontinued at 72 days of age. Conclusion It is important to strengthen the management of high-risk pregnant women with thyroid disease. Monitoring TRAb levels in both mothers and neonates should be done dynamically to enable early prediction and diagnosis of neonatal hyperthyroidism. Most neonates with hyperthyroidism have a good prognosis when timely and appropriate medical treatment is provided. |
| first_indexed | 2024-03-08T14:11:49Z |
| format | Article |
| id | doaj.art-0be62ce5fea0412eb1e8ee47975277e6 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-03-08T14:11:49Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-0be62ce5fea0412eb1e8ee47975277e62024-01-14T12:36:53ZengBMCBMC Pediatrics1471-24312024-01-012411710.1186/s12887-024-04531-6The tortuous diagnosis of one case of neonatal hyperthyroidismLin Zhu0Jing Wang1Wei Liu2Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Objective To outline the clinical signs, diagnosis, and course of care for a single case of neonatal hyperthyroidism while also summarizing common diagnostic errors related to this condition. Methods Medical records of the neonate of hyperthyroidism were collected and analyzed in combination with literature. Results The neonate’s mother had thyroid disease, but her thyrotropin receptor antibody (TRAb) levels were not monitored during pregnancy. The neonate exhibited typical symptoms of hyperthyroidism on the day of birth but was not diagnosed until 15 days later. Impaired liver (cholestasis, elevated liver enzymes) and cardiac function (pulmonary hypertension, right heart enlargement) are the main manifestations. Treatment with methimazole (1.0 mg /kg·d) and propranolol (2.0 mg /kg·d) led to recovery, and the neonate stayed in the hospital for 27 days before being discharged with medication. The diagnosis was temporary hyperthyroidism, and the medication was discontinued at 72 days of age. Conclusion It is important to strengthen the management of high-risk pregnant women with thyroid disease. Monitoring TRAb levels in both mothers and neonates should be done dynamically to enable early prediction and diagnosis of neonatal hyperthyroidism. Most neonates with hyperthyroidism have a good prognosis when timely and appropriate medical treatment is provided.https://doi.org/10.1186/s12887-024-04531-6HyperthyridismNewbornHepatic lesionMisdiagnosePrognosis |
| spellingShingle | Lin Zhu Jing Wang Wei Liu The tortuous diagnosis of one case of neonatal hyperthyroidism BMC Pediatrics Hyperthyridism Newborn Hepatic lesion Misdiagnose Prognosis |
| title | The tortuous diagnosis of one case of neonatal hyperthyroidism |
| title_full | The tortuous diagnosis of one case of neonatal hyperthyroidism |
| title_fullStr | The tortuous diagnosis of one case of neonatal hyperthyroidism |
| title_full_unstemmed | The tortuous diagnosis of one case of neonatal hyperthyroidism |
| title_short | The tortuous diagnosis of one case of neonatal hyperthyroidism |
| title_sort | tortuous diagnosis of one case of neonatal hyperthyroidism |
| topic | Hyperthyridism Newborn Hepatic lesion Misdiagnose Prognosis |
| url | https://doi.org/10.1186/s12887-024-04531-6 |
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