A study on the distribution of 85Sr and 134Cs radionuclides after total body irradiation
The kinetics of strontium, 85Sr, and cesium, 134Cs, were evaluated in a mouse experimental model to determine the impact of these radionuclides on a living organism concerning total body irradiation. Our study demonstrates that the elimination rate of 134Cs from the skeleton and teeth is in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
VINCA Institute of Nuclear Sciences
2020-01-01
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| Series: | Nuclear Technology and Radiation Protection |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/1451-3994/2020/1451-39942004361N.pdf |
| Summary: | The kinetics of strontium, 85Sr, and cesium, 134Cs, were evaluated in a
mouse experimental model to determine the impact of these radionuclides on a
living organism concerning total body irradiation. Our study demonstrates
that the elimination rate of 134Cs from the skeleton and teeth is influenced
by total body irradiation and the presence of 85Sr. Higher accumulation
and faster 134Cs elimination rates were observed in the skeleton and teeth
of mice administrated with a mixture of 134Cs + 85Sr radionuclides.
Regarding 85Sr, only a minimal effect was observed on its accumulation rate
in skeleton, teeth, and muscle in total body irradiation mice. The effect of
the 85Sr + 134Cs radionuclide mix on the accumulation of 85Sr was more
apparent in teeth, showing a higher retention rate after 10-24 days of
administration in non-irradiated mice. The evaluation of the kinetics of
these radionuclides provided much-needed insight on their effects during
the first two months after exposure, demonstrating that the accumulation
rate of 85Sr is greater than that of 134Cs. Further, the elimination rate of
the former is slower in comparison to the latter. Interestingly, total body
irradiation has a greater effect on the hematological parameters of the mice
blood than the radionuclides alone. |
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| ISSN: | 1451-3994 1452-8185 |