GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility
Autoimmune Addison’s disease is a rare complex disease, which has not yet been characterized by non-biased genetic studies. Here, the authors perform the first GWAS for the disease, identifying nine loci including two coding variants in the gene Autoimmune Regulator (AIRE).
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21015-8 |
| _version_ | 1818750526001512448 |
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| author | Daniel Eriksson Ellen Christine Røyrvik Maribel Aranda-Guillén Amund Holte Berger Nils Landegren Haydee Artaza Åsa Hallgren Marianne Aardal Grytaas Sara Ström Eirik Bratland Ileana Ruxandra Botusan Bergithe Eikeland Oftedal Lars Breivik Marc Vaudel Øyvind Helgeland Alberto Falorni Anders Palmstrøm Jørgensen Anna-Lena Hulting Johan Svartberg Olov Ekwall Kristian Johan Fougner Jeanette Wahlberg Bjørn Gunnar Nedrebø Per Dahlqvist The Norwegian Addison Registry Study Group The Swedish Addison Registry Study Group Per Morten Knappskog Anette Susanne Bøe Wolff Sophie Bensing Stefan Johansson Olle Kämpe Eystein Sverre Husebye |
| author_facet | Daniel Eriksson Ellen Christine Røyrvik Maribel Aranda-Guillén Amund Holte Berger Nils Landegren Haydee Artaza Åsa Hallgren Marianne Aardal Grytaas Sara Ström Eirik Bratland Ileana Ruxandra Botusan Bergithe Eikeland Oftedal Lars Breivik Marc Vaudel Øyvind Helgeland Alberto Falorni Anders Palmstrøm Jørgensen Anna-Lena Hulting Johan Svartberg Olov Ekwall Kristian Johan Fougner Jeanette Wahlberg Bjørn Gunnar Nedrebø Per Dahlqvist The Norwegian Addison Registry Study Group The Swedish Addison Registry Study Group Per Morten Knappskog Anette Susanne Bøe Wolff Sophie Bensing Stefan Johansson Olle Kämpe Eystein Sverre Husebye |
| author_sort | Daniel Eriksson |
| collection | DOAJ |
| description | Autoimmune Addison’s disease is a rare complex disease, which has not yet been characterized by non-biased genetic studies. Here, the authors perform the first GWAS for the disease, identifying nine loci including two coding variants in the gene Autoimmune Regulator (AIRE). |
| first_indexed | 2024-12-18T04:21:04Z |
| format | Article |
| id | doaj.art-0be85e9204274eff9b1cb72be80b2205 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:21:04Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0be85e9204274eff9b1cb72be80b22052022-12-21T21:21:13ZengNature PortfolioNature Communications2041-17232021-02-0112111410.1038/s41467-021-21015-8GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibilityDaniel Eriksson0Ellen Christine Røyrvik1Maribel Aranda-Guillén2Amund Holte Berger3Nils Landegren4Haydee Artaza5Åsa Hallgren6Marianne Aardal Grytaas7Sara Ström8Eirik Bratland9Ileana Ruxandra Botusan10Bergithe Eikeland Oftedal11Lars Breivik12Marc Vaudel13Øyvind Helgeland14Alberto Falorni15Anders Palmstrøm Jørgensen16Anna-Lena Hulting17Johan Svartberg18Olov Ekwall19Kristian Johan Fougner20Jeanette Wahlberg21Bjørn Gunnar Nedrebø22Per Dahlqvist23The Norwegian Addison Registry Study GroupThe Swedish Addison Registry Study GroupPer Morten Knappskog24Anette Susanne Bøe Wolff25Sophie Bensing26Stefan Johansson27Olle Kämpe28Eystein Sverre Husebye29Centre for Molecular Medicine, Department of Medicine (Solna), Karolinska InstitutetDepartment of Clinical Science, University of BergenCentre for Molecular Medicine, Department of Medicine (Solna), Karolinska InstitutetDepartment of Clinical Science, University of BergenCentre for Molecular Medicine, Department of Medicine (Solna), Karolinska InstitutetDepartment of Clinical Science, University of BergenCentre for Molecular Medicine, Department of Medicine (Solna), Karolinska InstitutetDepartment of Clinical Science, University of BergenDepartment of Endocrinology, Metabolism and Diabetes, Karolinska University HospitalDepartment of Clinical Science, University of BergenDepartment of Endocrinology, Metabolism and Diabetes, Karolinska University HospitalDepartment of Clinical Science, University of BergenDepartment of Clinical Science, University of BergenCenter for Diabetes Research, Department of Clinical Science, University of BergenCenter for Diabetes Research, Department of Clinical Science, University of BergenDepartment of Medicine, University of PerugiaSection of Specialized Endocrinology, Department of Endocrinology, Oslo University HospitalDepartment of Molecular Medicine and Surgery, Karolinska InstitutetTromsø Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of NorwayDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of GothenburgDepartment of Endocrinology, St. Olavs HospitalDepartment of Endocrinology, Linköping UniversityDepartment of Clinical Science, University of BergenDepartment of Public Health and Clinical Medicine, Umeå UniversityDepartment of Clinical Science, University of BergenDepartment of Clinical Science, University of BergenDepartment of Endocrinology, Metabolism and Diabetes, Karolinska University HospitalDepartment of Clinical Science, University of BergenCentre for Molecular Medicine, Department of Medicine (Solna), Karolinska InstitutetCentre for Molecular Medicine, Department of Medicine (Solna), Karolinska InstitutetAutoimmune Addison’s disease is a rare complex disease, which has not yet been characterized by non-biased genetic studies. Here, the authors perform the first GWAS for the disease, identifying nine loci including two coding variants in the gene Autoimmune Regulator (AIRE).https://doi.org/10.1038/s41467-021-21015-8 |
| spellingShingle | Daniel Eriksson Ellen Christine Røyrvik Maribel Aranda-Guillén Amund Holte Berger Nils Landegren Haydee Artaza Åsa Hallgren Marianne Aardal Grytaas Sara Ström Eirik Bratland Ileana Ruxandra Botusan Bergithe Eikeland Oftedal Lars Breivik Marc Vaudel Øyvind Helgeland Alberto Falorni Anders Palmstrøm Jørgensen Anna-Lena Hulting Johan Svartberg Olov Ekwall Kristian Johan Fougner Jeanette Wahlberg Bjørn Gunnar Nedrebø Per Dahlqvist The Norwegian Addison Registry Study Group The Swedish Addison Registry Study Group Per Morten Knappskog Anette Susanne Bøe Wolff Sophie Bensing Stefan Johansson Olle Kämpe Eystein Sverre Husebye GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility Nature Communications |
| title | GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility |
| title_full | GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility |
| title_fullStr | GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility |
| title_full_unstemmed | GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility |
| title_short | GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility |
| title_sort | gwas for autoimmune addison s disease identifies multiple risk loci and highlights aire in disease susceptibility |
| url | https://doi.org/10.1038/s41467-021-21015-8 |
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