Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays

Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays

Abstract Background The pathways that control protein transport across the blood–brain barrier (BBB) remain poorly characterized. Despite great advances in recapitulating the human BBB in vitro, current models are not suitable for systematic analysis of the molecular mechanisms of antibody transport...

Full description

Bibliographic Details
Main Authors:	Claire Simonneau, Martina Duschmalé, Alina Gavrilov, Nathalie Brandenberg, Sylke Hoehnel, Camilla Ceroni, Evodie Lassalle, Elena Kassianidou, Hendrik Knoetgen, Jens Niewoehner, Roberto Villaseñor
Format:	Article
Language:	English
Published:	BMC 2021-09-01
Series:	Fluids and Barriers of the CNS
Subjects:	Blood–brain barrier Organoids Receptor-mediated transcytosis High-throughput in vitro model
Online Access:	https://doi.org/10.1186/s12987-021-00276-x

Similar Items

Endothelial Transcytosis of Lipoproteins in Atherosclerosis
by: Xinbo Zhang, et al.
Published: (2018-09-01)

Sorting Tubules Regulate Blood-Brain Barrier Transcytosis
by: Roberto Villaseñor, et al.
Published: (2017-12-01)

Biodistribution of Liposome-Encapsulated Bacteriophages and Their Transcytosis During Oral Phage Therapy
by: Jennifer Otero, et al.
Published: (2019-04-01)

A New Pathogenesis of Albuminuria: Role of Transcytosis
by: Fang-Fang He, et al.
Published: (2018-06-01)

The Role of BAR Proteins and the Glycocalyx in Brain Endothelium Transcytosis
by: Diana M. Leite, et al.
Published: (2020-12-01)

Caveolae-Mediated Endothelial Transcytosis across the Blood-Brain Barrier in Acute Ischemic Stroke
by: Min Zhou, et al.
Published: (2021-08-01)

Major effect of transcytosis on nano drug delivery to pancreatic cancer
by: Xiangsheng Liu, et al.
Published: (2017-07-01)

Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges
by: Victor M. Pulgar, et al.
Published: (2019-01-01)

Macromolecule Translocation across the Intestinal Mucosa of HIV-Infected Patients by Transcytosis and through Apoptotic Leaks
by: Susanne M. Krug, et al.
Published: (2023-07-01)

Storax Inhibits Caveolae-Mediated Transcytosis at Blood-Brain Barrier After Ischemic Stroke in Rats
by: Min Zhou, et al.
Published: (2022-07-01)

Apolipoprotein A1 and high-density lipoprotein limit low-density lipoprotein transcytosis by binding SR-B1
by: Karen Y.Y. Fung, et al.
Published: (2024-04-01)

Overview of Crosstalk Between Multiple Factor of Transcytosis in Blood Brain Barrier
by: Marco Tjakra, et al.
Published: (2020-01-01)

Smuggling Drugs into the Brain: An Overview of Ligands Targeting Transcytosis for Drug Delivery across the Blood–Brain Barrier
by: Julia V. Georgieva, et al.
Published: (2014-11-01)

Intestinal Transcytosis of a Protein Cargo and Nanoparticles Mediated by a Non-Toxic Form of <i>Pseudomonas aeruginosa</i> Exotoxin A
by: Ruiying Li, et al.
Published: (2021-07-01)

Receptor-mediated transcytosis for brain delivery of therapeutics: receptor classes and criteria
by: Arsalan S. Haqqani, et al.
Published: (2024-03-01)

RETRACTED: Endocytic recycling and vesicular transport systems mediate transcytosis of Leptospira interrogans across cell monolayer
by: Yang Li, et al.
Published: (2019-04-01)

Alpha-Gal on the Protein Surface Hampers Transcytosis through the Caco-2 Monolayer
by: Maja Krstić Ristivojević, et al.
Published: (2020-08-01)

Both the Complexity of Tight Junctions and Endothelial Transcytosis Are Increased During BBB Postnatal Development in Rats
by: Wei Li, et al.
Published: (2022-04-01)

AGEs promote atherosclerosis by increasing LDL transcytosis across endothelial cells via RAGE/NF-κB/Caveolin-1 pathway
by: Meng Shu, et al.
Published: (2023-08-01)

Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor
by: Niloufar Monhasery, et al.
Published: (2016-07-01)

Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer’s Disease Mutations
by: Grace Woodruff, et al.
Published: (2016-10-01)

Stimuli‐Responsive Nanocarriers for Transcytosis‐Based Cancer Drug Delivery
by: Zhehao Wang, et al.
Published: (2024-03-01)

Transcytosis Involvement in Transport System and Endothelial Permeability of Vascular Leakage during Dengue Virus Infection
by: Chanettee Chanthick, et al.
Published: (2018-02-01)

Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers
by: Parvez Alam, et al.
Published: (2022-05-01)

Protocol for drug screening of patient-derived tumor organoids using high-content fluorescent imaging
by: Brian M. Larsen, et al.
Published: (2022-06-01)

CRP-Induced NLRP3 Inflammasome Activation Increases LDL Transcytosis Across Endothelial Cells
by: Fang Bian, et al.
Published: (2019-01-01)

Towards automatization of organoid analysis: A deep learning approach to localize and quantify organoid images
by: Asmaa Haja, et al.
Published: (2023-01-01)

Affibody Molecules Intended for Receptor-Mediated Transcytosis via the Transferrin Receptor
by: Linnea Charlotta Hjelm, et al.
Published: (2023-07-01)

Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier
by: Mikkel Roland Holst, et al.
Published: (2023-11-01)

Orange-derived extracellular vesicles nanodrugs for efficient treatment of ovarian cancer assisted by transcytosis effect
by: Feng Long, et al.
Published: (2023-12-01)

Complement Receptor 3 Mediates HIV-1 Transcytosis across an Intact Cervical Epithelial Cell Barrier: New Insight into HIV Transmission in Women
by: Christopher J. Day, et al.
Published: (2022-02-01)

Diagnostic tools and CFTR functional assays in cystic fibrosis: utility and availability in Switzerland
by: Clara Fernandez Elviro, et al.
Published: (2021-04-01)

Normal and tumor-derived organoids as a drug screening platform for tumor-specific drug vulnerabilities
by: Camilla Calandrini, et al.
Published: (2022-03-01)

Quantification of cell death and proliferation of patient-derived ovarian cancer organoids through 3D imaging and image analysis
by: Aikaterini Skorda, et al.
Published: (2023-12-01)

Mfsd2a (Major Facilitator Superfamily Domain Containing 2a) Attenuates Intracerebral Hemorrhage–Induced Blood–Brain Barrier Disruption by Inhibiting Vesicular Transcytosis
by: Yuan‐Rui Yang, et al.
Published: (2017-07-01)

Assay establishment and validation of a high-throughput organoid-based drug screening platform
by: Xiaomeng Li, et al.
Published: (2022-05-01)

In Situ Vitrification of Lung Cancer Organoids on a Microwell Array
by: Qiang Liu, et al.
Published: (2021-05-01)

C-kit controls blood-brain barrier permeability by regulating caveolae-mediated transcytosis after chronic cerebral hypoperfusion
by: Junkui Shang, et al.
Published: (2024-01-01)

Human Organoids for Predictive Toxicology Research and Drug Development
by: Toshikatsu Matsui, et al.
Published: (2021-11-01)

Treatment of Neuronopathic Mucopolysaccharidoses with Blood–Brain Barrier-Crossing Enzymes: Clinical Application of Receptor-Mediated Transcytosis
by: Hiroyuki Sonoda, et al.
Published: (2022-06-01)