Protective and therapeutic effect of quercetin in hepatotoxicity induced by sepsis in rats
Septicemia caused by Gram-negative bacteria is an infection associated with liver dysfunction. Quercetin is a natural flavonoid found in vegetables and fruits and has anti-inflammatory, antioxidant, cytoprotective and antiallergic properties. This research aims to investigate the effects of querceti...
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2021-11-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
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| Online Access: | https://vetdergikafkas.org/pdf.php?id=2862 |
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| author | Mevlüt DOĞUKAN Murat BIÇAKCIOĞLU Mehmet DURAN Zümrüt DOĞAN Bilge AYDIN TÜRK Öznur ULUDAĞ |
| author_facet | Mevlüt DOĞUKAN Murat BIÇAKCIOĞLU Mehmet DURAN Zümrüt DOĞAN Bilge AYDIN TÜRK Öznur ULUDAĞ |
| author_sort | Mevlüt DOĞUKAN |
| collection | DOAJ |
| description | Septicemia caused by Gram-negative bacteria is an infection associated with liver dysfunction. Quercetin is a natural flavonoid found in vegetables and fruits and has anti-inflammatory, antioxidant, cytoprotective and antiallergic properties. This research aims to investigate the effects of quercetin on the liver against tissue damage due to sepsis-induced oxidative stress. Thirty-two male rats were used in the study. The animals were randomly divided into 5 groups. Quercetin was dissolved in 20 mg/kg of olive oil daily for 15 days and given through oral gavage. The cecal-ligation sepsis model was applied to the group 3 and group 4. In histopathological evaluation; inflammation involving moderate neutrophils and lymphocytes was observed in most portal areas in the group where sepsis was created (Group 3). In the sepsis group administered quercetin (Group 4) only a few portal areas had a milder inflammation with fewer neutrophils than the sepsis group. There was a significant difference between group 3, 4, and all other groups in ALT and AST values. A significant difference was observed between group 3, 4 and other groups in terms of tissue MDA, GSH levels. It was concluded that quercetin, a powerful antioxidant, can reduce liver damage caused by sepsis and has the potential to be used to help treat sepsis. |
| first_indexed | 2024-03-13T04:38:57Z |
| format | Article |
| id | doaj.art-0bee21e8c0454baca139d008f7de6da3 |
| institution | Directory Open Access Journal |
| issn | 1309-2251 |
| language | English |
| last_indexed | 2024-03-13T04:38:57Z |
| publishDate | 2021-11-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-0bee21e8c0454baca139d008f7de6da32023-06-19T06:28:52ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512021-11-0127669970610.9775/kvfd.2021.261352862Protective and therapeutic effect of quercetin in hepatotoxicity induced by sepsis in ratsMevlüt DOĞUKAN0Murat BIÇAKCIOĞLU1Mehmet DURANZümrüt DOĞAN2Bilge AYDIN TÜRK3Öznur ULUDAĞ4Anesthesiology and Reanimation Department, Adiyaman University Faculty of Medicine, TR-02100 Adiyaman - TURKEYAnesthesiology and Reanimation Department, Balıkesir University Faculty of Medicine, TR-10010 Balıkesir - TURKEYAnatomy Department, Adiyaman University Faculty of Medicine, TR-02100 Adiyaman - TURKEYPathology Department, Adiyaman University Faculty of Medicine, TR-02100 Adiyaman - TURKEYAnesthesiology and Reanimation Department, Adiyaman University Faculty of Medicine, TR-02100 Adiyaman - TURKEYSepticemia caused by Gram-negative bacteria is an infection associated with liver dysfunction. Quercetin is a natural flavonoid found in vegetables and fruits and has anti-inflammatory, antioxidant, cytoprotective and antiallergic properties. This research aims to investigate the effects of quercetin on the liver against tissue damage due to sepsis-induced oxidative stress. Thirty-two male rats were used in the study. The animals were randomly divided into 5 groups. Quercetin was dissolved in 20 mg/kg of olive oil daily for 15 days and given through oral gavage. The cecal-ligation sepsis model was applied to the group 3 and group 4. In histopathological evaluation; inflammation involving moderate neutrophils and lymphocytes was observed in most portal areas in the group where sepsis was created (Group 3). In the sepsis group administered quercetin (Group 4) only a few portal areas had a milder inflammation with fewer neutrophils than the sepsis group. There was a significant difference between group 3, 4, and all other groups in ALT and AST values. A significant difference was observed between group 3, 4 and other groups in terms of tissue MDA, GSH levels. It was concluded that quercetin, a powerful antioxidant, can reduce liver damage caused by sepsis and has the potential to be used to help treat sepsis.https://vetdergikafkas.org/pdf.php?id=2862quercetinsepsishepatotoxicityrat |
| spellingShingle | Mevlüt DOĞUKAN Murat BIÇAKCIOĞLU Mehmet DURAN Zümrüt DOĞAN Bilge AYDIN TÜRK Öznur ULUDAĞ Protective and therapeutic effect of quercetin in hepatotoxicity induced by sepsis in rats Kafkas Universitesi Veteriner Fakültesi Dergisi quercetin sepsis hepatotoxicity rat |
| title | Protective and therapeutic effect of quercetin in hepatotoxicity induced by sepsis in rats |
| title_full | Protective and therapeutic effect of quercetin in hepatotoxicity induced by sepsis in rats |
| title_fullStr | Protective and therapeutic effect of quercetin in hepatotoxicity induced by sepsis in rats |
| title_full_unstemmed | Protective and therapeutic effect of quercetin in hepatotoxicity induced by sepsis in rats |
| title_short | Protective and therapeutic effect of quercetin in hepatotoxicity induced by sepsis in rats |
| title_sort | protective and therapeutic effect of quercetin in hepatotoxicity induced by sepsis in rats |
| topic | quercetin sepsis hepatotoxicity rat |
| url | https://vetdergikafkas.org/pdf.php?id=2862 |
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