TIME FOR RADICAL CHANGE OF UNIVERSAL MYOCARDIAL INFARCTION DEFINITION HAS ARRIVED YESTERDAY
In this manuscript, we discuss a previously introduced definition of the myocardial infarction (MI), and propose to redefine it so it is not limited just to “a necrosis in the setting of myocardial ischemia”, which we think is the case only in the deceased individuals that died during the first few...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
V. N. Karazin Kharkiv National University
2017-12-01
|
| Series: | Journal of V. N. Karazin Kharkiv National University: Series Medicine |
| Subjects: | |
| Online Access: | http://periodicals.karazin.ua/medicine/article/view/10030/9553 |
| _version_ | 1811206028042174464 |
|---|---|
| author | Yabluchanskiy M. I. Yabluchanskiy A. M. |
| author_facet | Yabluchanskiy M. I. Yabluchanskiy A. M. |
| author_sort | Yabluchanskiy M. I. |
| collection | DOAJ |
| description | In this manuscript, we discuss a previously introduced definition of the myocardial infarction (MI), and propose to redefine it so it is not limited just to “a necrosis in the setting of myocardial ischemia”, which we think is the case only in the deceased individuals that died during the first few hours from the MI onset, but to include a broader description of the acute aseptic coronarogenic inflammation of the cardiac muscle. We suggest that the outcome of the MI to a large extant depends on the synchronization of the necrotic and reparative processes and that their desynchronization ultimately results in the development of MI complications. A better understanding of the MI and the use of appropriate definition is warranted for a development of new therapeutic targets. |
| first_indexed | 2024-04-12T03:40:35Z |
| format | Article |
| id | doaj.art-0bee46c3c15e4cb394186c1c77d27b34 |
| institution | Directory Open Access Journal |
| issn | 2313-6693 2313-2396 |
| language | English |
| last_indexed | 2024-04-12T03:40:35Z |
| publishDate | 2017-12-01 |
| publisher | V. N. Karazin Kharkiv National University |
| record_format | Article |
| series | Journal of V. N. Karazin Kharkiv National University: Series Medicine |
| spelling | doaj.art-0bee46c3c15e4cb394186c1c77d27b342022-12-22T03:49:17ZengV. N. Karazin Kharkiv National UniversityJournal of V. N. Karazin Kharkiv National University: Series Medicine2313-66932313-23962017-12-013456TIME FOR RADICAL CHANGE OF UNIVERSAL MYOCARDIAL INFARCTION DEFINITION HAS ARRIVED YESTERDAYYabluchanskiy M. I.Yabluchanskiy A. M.In this manuscript, we discuss a previously introduced definition of the myocardial infarction (MI), and propose to redefine it so it is not limited just to “a necrosis in the setting of myocardial ischemia”, which we think is the case only in the deceased individuals that died during the first few hours from the MI onset, but to include a broader description of the acute aseptic coronarogenic inflammation of the cardiac muscle. We suggest that the outcome of the MI to a large extant depends on the synchronization of the necrotic and reparative processes and that their desynchronization ultimately results in the development of MI complications. A better understanding of the MI and the use of appropriate definition is warranted for a development of new therapeutic targets.http://periodicals.karazin.ua/medicine/article/view/10030/9553myocardial infarctioninflammation |
| spellingShingle | Yabluchanskiy M. I. Yabluchanskiy A. M. TIME FOR RADICAL CHANGE OF UNIVERSAL MYOCARDIAL INFARCTION DEFINITION HAS ARRIVED YESTERDAY Journal of V. N. Karazin Kharkiv National University: Series Medicine myocardial infarction inflammation |
| title | TIME FOR RADICAL CHANGE OF UNIVERSAL MYOCARDIAL INFARCTION DEFINITION HAS ARRIVED YESTERDAY |
| title_full | TIME FOR RADICAL CHANGE OF UNIVERSAL MYOCARDIAL INFARCTION DEFINITION HAS ARRIVED YESTERDAY |
| title_fullStr | TIME FOR RADICAL CHANGE OF UNIVERSAL MYOCARDIAL INFARCTION DEFINITION HAS ARRIVED YESTERDAY |
| title_full_unstemmed | TIME FOR RADICAL CHANGE OF UNIVERSAL MYOCARDIAL INFARCTION DEFINITION HAS ARRIVED YESTERDAY |
| title_short | TIME FOR RADICAL CHANGE OF UNIVERSAL MYOCARDIAL INFARCTION DEFINITION HAS ARRIVED YESTERDAY |
| title_sort | time for radical change of universal myocardial infarction definition has arrived yesterday |
| topic | myocardial infarction inflammation |
| url | http://periodicals.karazin.ua/medicine/article/view/10030/9553 |
| work_keys_str_mv | AT yabluchanskiymi timeforradicalchangeofuniversalmyocardialinfarctiondefinitionhasarrivedyesterday AT yabluchanskiyam timeforradicalchangeofuniversalmyocardialinfarctiondefinitionhasarrivedyesterday |