Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer
Abstract Papillary carcinomas account for the largest proportion of thyroid cancers, with papillary thyroid carcinoma (PTC) being prone to early lymph node metastasis. Some studies have confirmed that LPAR5 can promote the progression of PTC, but immune-related analyses of LPAR5 and PTC have not bee...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32733-y |
| _version_ | 1797845989154881536 |
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| author | Ben Zhang Lixi Zhang Peng Qi Renzhu Pang Ziming Wang Xuyao Liu Qi Shi Qiang Zhang |
| author_facet | Ben Zhang Lixi Zhang Peng Qi Renzhu Pang Ziming Wang Xuyao Liu Qi Shi Qiang Zhang |
| author_sort | Ben Zhang |
| collection | DOAJ |
| description | Abstract Papillary carcinomas account for the largest proportion of thyroid cancers, with papillary thyroid carcinoma (PTC) being prone to early lymph node metastasis. Some studies have confirmed that LPAR5 can promote the progression of PTC, but immune-related analyses of LPAR5 and PTC have not been widely discussed. This study aimed to determine the role of LPAR5 in PTC prognosis and immunity. We will further explore the role of LPAR5 in 33 different tumor types. Regarding PTC, we analyzed the effect of LPAR5 expression on overall survival (OS). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed. Immune-related analyses of immune checkpoints (ICPs) and immune cell infiltration were also performed. For pan-cancer, R packages were used to analyze prognosis, tumor mutational burden (TMB), microsatellite instability (MSI), and immune cell infiltration. Analysis of tumor microenvironment (TME) and ICPs was performed using Sangerbox ( http://vip.sangerbox.com/home.html ). The TISIDB database ( http://cis.hku.hk/TISIDB/index.php ) was used to identify immune and molecular subtypes. LPAR5 expression is associated with PTC prognosis and immunity as well as various human tumors. LPAR5 may be a potential biomarker for multiple malignancies and may provide a new target for cancer immunotherapy. |
| first_indexed | 2024-04-09T17:47:49Z |
| format | Article |
| id | doaj.art-0bf29e985bdc4129be95c27aa14c540b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T17:47:49Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0bf29e985bdc4129be95c27aa14c540b2023-04-16T11:11:47ZengNature PortfolioScientific Reports2045-23222023-04-0113111410.1038/s41598-023-32733-yPotential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancerBen Zhang0Lixi Zhang1Peng Qi2Renzhu Pang3Ziming Wang4Xuyao Liu5Qi Shi6Qiang Zhang7Thyroid Surgery Department, General Surgery Center, First Hospital of Jilin UniversityThyroid Surgery Department, General Surgery Center, First Hospital of Jilin UniversityThyroid Surgery Department, General Surgery Center, First Hospital of Jilin UniversityThyroid Surgery Department, General Surgery Center, First Hospital of Jilin UniversityThyroid Surgery Department, General Surgery Center, First Hospital of Jilin UniversityThyroid Surgery Department, General Surgery Center, First Hospital of Jilin UniversityThyroid Surgery Department, General Surgery Center, First Hospital of Jilin UniversityThyroid Surgery Department, General Surgery Center, First Hospital of Jilin UniversityAbstract Papillary carcinomas account for the largest proportion of thyroid cancers, with papillary thyroid carcinoma (PTC) being prone to early lymph node metastasis. Some studies have confirmed that LPAR5 can promote the progression of PTC, but immune-related analyses of LPAR5 and PTC have not been widely discussed. This study aimed to determine the role of LPAR5 in PTC prognosis and immunity. We will further explore the role of LPAR5 in 33 different tumor types. Regarding PTC, we analyzed the effect of LPAR5 expression on overall survival (OS). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed. Immune-related analyses of immune checkpoints (ICPs) and immune cell infiltration were also performed. For pan-cancer, R packages were used to analyze prognosis, tumor mutational burden (TMB), microsatellite instability (MSI), and immune cell infiltration. Analysis of tumor microenvironment (TME) and ICPs was performed using Sangerbox ( http://vip.sangerbox.com/home.html ). The TISIDB database ( http://cis.hku.hk/TISIDB/index.php ) was used to identify immune and molecular subtypes. LPAR5 expression is associated with PTC prognosis and immunity as well as various human tumors. LPAR5 may be a potential biomarker for multiple malignancies and may provide a new target for cancer immunotherapy.https://doi.org/10.1038/s41598-023-32733-y |
| spellingShingle | Ben Zhang Lixi Zhang Peng Qi Renzhu Pang Ziming Wang Xuyao Liu Qi Shi Qiang Zhang Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer Scientific Reports |
| title | Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer |
| title_full | Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer |
| title_fullStr | Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer |
| title_full_unstemmed | Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer |
| title_short | Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer |
| title_sort | potential role of lpar5 gene in prognosis and immunity of thyroid papillary carcinoma and pan cancer |
| url | https://doi.org/10.1038/s41598-023-32733-y |
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